Interactor 1: ALKB8 (Q96BT7)
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 (EC 2.1.1.229) (Alkylated DNA repair protein alkB homolog 8) (Alpha-ketoglutarate-dependent dioxygenase ALKBH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8)
Gene: ALKBH8

Interactor 2: TR112 (Q9UI30)
Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)
Gene: TRMT112

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.849

The method score is based on:

Property Details
Experiments 34948388, 20123966, 20308323
Identification Methods anti tag coimmunoprecipitation, two hybrid, pull down
Interaction Type association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Methyltransf_11~Trm112p
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030488 - tRNA methylation
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 664
Hs

1 125
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025