Protein: TR112
Multifunctional methyltransferase subunit TRM112 (eRF1 methyltransferase subunit TRM112) (eRF1 MTase subunit TRM112) (tRNA methyltransferase 112)

Gene: TR112, TRM112
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P53738

Gene Ontology (top 5):
GO:0000470 - maturation of LSU-rRNA
GO:0002098 - tRNA wobble uridine modification
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923058

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

9

2

Small-scale

0.970

High

892821

TRM9
tRNA

9

1

Small-scale

0.967

High

923069

TRM11
tRNA

8

1

Small-scale

0.967

High

678248

BUD23
18S rRNA

5

2

Small-scale

0.931

High

808806

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

3

0

Small-scale

0.634

High

923059

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

Small-scale

0.634

High

923051

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.586

High

830150

NOP2
25S rRNA

2

1

Small-scale

0.584

High

923065

TSR1
Ribosome biogenesis protein TSR1

2

0

Small-scale

0.559

High

819401

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

923064

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.486

High

645959

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.480

High

748884

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

792727

YPK3
Serine/threonine-protein kinase YPK3

1

0

High-throughput

0.480

High

794283

CHK1
Serine/threonine-protein kinase CHK1

1

0

High-throughput

0.480

High

835985

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

0

High-throughput

0.480

High

923068

KPR5
Ribose-phosphate pyrophosphokinase 5

1

0

High-throughput

0.480

High

923071

SKM1
Serine/threonine-protein kinase SKM1

1

0

High-throughput

0.480

High

632580

DBP3
ATP-dependent RNA helicase DBP3

1

1

Small-scale

0.479

High

666510

DBP2
ATP-dependent RNA helicase DBP2

1

1

Small-scale

0.479

High

694604

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

798278

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

923053

RCM1
25S rRNA

1

1

Small-scale

0.479

High

923057

HAS1
ATP-dependent RNA helicase HAS1

1

1

Small-scale

0.479

High

923061

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

Small-scale

0.479

High

923062

ERB1
Ribosome biogenesis protein ERB1

1

1

Small-scale

0.479

High

826041

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.460

High

383822

RS17A
Small ribosomal subunit protein eS17A

1

0

Small-scale

0.458

High

410259

RL25
Large ribosomal subunit protein uL23

1

0

Small-scale

0.458

High

435611

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.458

High

436476

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

513392

RL23B
Large ribosomal subunit protein uL14B

1

0

Small-scale

0.458

High

513894

RS11B
Small ribosomal subunit protein uS17B

1

0

Small-scale

0.458

High

515295

RL35A
Large ribosomal subunit protein uL29A

1

0

Small-scale

0.458

High

518092

SSBP1
Single-stranded nucleic acid-binding protein

1

0

Small-scale

0.458

High

534291

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

Small-scale

0.458

High

553639

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

570093

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

584930

TRM1
tRNA

1

0

Small-scale

0.458

High

585328

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

601097

RL8A
Large ribosomal subunit protein eL8A

1

0

Small-scale

0.458

High

644963

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

Small-scale

0.458

High

684800

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.458

High

688931

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.458

High

707798

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

751444

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

Small-scale

0.458

High

806483

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

814016

IF2P
Eukaryotic translation initiation factor 5B

1

0

Small-scale

0.458

High

817274

ARB1
ABC transporter ATP-binding protein ARB1

1

0

Small-scale

0.458

High

817918

IMB4
Importin subunit beta-4

1

0

Small-scale

0.458

High

858039

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.458

High

870668

RS7B
Small ribosomal subunit protein eS7B

1

0

Small-scale

0.458

High

918602

SLX9
Ribosome biogenesis protein SLX9

1

0

High-throughput

0.458

High

918935

PESC
Pescadillo homolog

1

0

Small-scale

0.458

High

923052

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.458

High

923055

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

Small-scale

0.458

High

923056

NOG1
Nucleolar GTP-binding protein 1

1

0

Small-scale

0.458

High

923060

TYW2
tRNA wybutosine-synthesizing protein 2

1

0

Small-scale

0.458

High

923063

RRP5
rRNA biogenesis protein RRP5

1

0

Small-scale

0.458

High

923066

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.458

High

923067

MDN1
Midasin

1

0

Small-scale

0.458

High

923070

RUVB2
RuvB-like protein 2

1

0

Small-scale

0.458

High

923072

RRP12
Ribosomal RNA-processing protein 12

1

0

Small-scale

0.458

High

545767

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

821024

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

Small-scale

0.437

High

524725

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

863679

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

796816

EXO84
Exocyst complex component EXO84

2

0

High-throughput

0.295

High

427732

RLA2
Large ribosomal subunit protein P2A

1

0

Small-scale

0.249

Low

438464

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.249

Low

923054

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025