HitPredict

Interactor 1: KMT2B (O08550)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Interactor 2: H33 (P84244)
Histone H3.3
Gene: H3-3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17707229
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2713 Mm			1 136
+	Hs
		935368 KMT2B_HUMAN (1-2713): 0: 1096: 85.50		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952698 KMT2B_HUMAN (1-2713): 0: 1096: 85.50		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1174689 KMT2B_HUMAN (1-2713): 0: 1096: 85.50		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		828421 KMT2B_HUMAN (1-2713): 0: 1096: 85.50		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		165661 SET1A_HUMAN (2260-2713): 9.04e-81: 299: 26.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Dm
		356067 TRX_DROME (1812-2713): 1.09e-80: 301: 22.58		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Hs
		165688 SET1A_HUMAN (2260-2713): 9.04e-81: 299: 26.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		93307 SET1A_MOUSE (2249-2713): 3.21e-76: 284: 25.37		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		935237 SUV92_HUMAN (2351-2713): 1.48e-81: 277: 19.90		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952627 SUV92_HUMAN (2351-2713): 1.48e-81: 277: 19.90		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		203659 SUV91_HUMAN (2371-2712): 5.65e-80: 273: 17.47		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		203664 SUV91_HUMAN (2371-2712): 5.65e-80: 273: 17.47		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		203722 SUV91_HUMAN (2371-2712): 5.65e-80: 273: 17.47		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Sp
		457194 SET1_SCHPO (2139-2713): 6.77e-75: 272: 21.42		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Hs
		935276 ASH1L_HUMAN (2021-2712): 3.44e-70: 266: 14.11		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		203706 SUV91_HUMAN (2371-2712): 5.65e-80: 273: 17.47		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		952649 ASH1L_HUMAN (2021-2712): 3.44e-70: 266: 14.11		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		203711 SUV91_HUMAN (2371-2712): 5.65e-80: 273: 17.47		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Sc
		755791 SET1_YEAST (2265-2713): 8.44e-76: 278: 23.92		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Dm
		356118 ASH1_DROME (2076-2712): 5.44e-66: 252: 18.40		H3_DROME (1-136): 5.32e-59: 180: 97.06