Protein: RMD5A
E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)

Gene: RMD5A, RMND5A
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q9H871

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1402308

RANB9
Ran-binding protein 9

11

20

Small-scale

0.977

High

1436197

GID8
Glucose-induced degradation protein 8 homolog

9

17

Small-scale

0.974

High

1272749

MAEA
E3 ubiquitin-protein transferase MAEA

9

16

Small-scale

0.972

High

1250526

RBP10
Ran-binding protein 10

6

19

High-throughput

0.950

High

1391442

RMD5B
E3 ubiquitin-protein transferase RMND5B

3

16

High-throughput

0.839

High

1436191

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

15

Small-scale

0.768

High

1307930

ARMC8
Armadillo repeat-containing protein 8

7

6

Small-scale

0.745

High

1309313

GID4
Glucose-induced degradation protein 4 homolog

6

5

Small-scale

0.733

High

1435660

WDR26
WD repeat-containing protein 26

6

10

Small-scale

0.733

High

1436205

MKLN1
Muskelin

6

8

Small-scale

0.733

High

977162

YPEL5
Protein yippee-like 5

5

9

High-throughput

0.714

High

216820

HTRA2
Serine protease HTRA2, mitochondrial

4

3

High-throughput

0.694

High

1388500

ZMY19
Zinc finger MYND domain-containing protein 19

4

2

High-throughput

0.694

High

1436202

TCAL9
Transcription elongation factor A protein-like 9

4

3

High-throughput

0.691

High

1220138

PAPD7
Terminal nucleotidyltransferase 4A

3

2

High-throughput

0.667

High

1104677

IKZF1
DNA-binding protein Ikaros

3

3

High-throughput

0.662

High

248351

HBP1
HMG box-containing protein 1

3

9

High-throughput

0.656

High

555428

SKI
Ski oncogene

3

3

High-throughput

0.650

High

1436200

SYWM
Tryptophan--tRNA ligase, mitochondrial

3

0

High-throughput

0.638

High

230666

PRIC3
Prickle planar cell polarity protein 3

2

4

High-throughput

0.628

High

562762

BMP1
Bone morphogenetic protein 1

2

5

High-throughput

0.628

High

1198321

TIGD5
Tigger transposable element-derived protein 5

2

2

High-throughput

0.628

High

242947

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

543288

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.618

High

971094

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

High-throughput

0.618

High

1100390

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.618

High

1436194

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

6

High-throughput

0.618

High

61642

VWA8
von Willebrand factor A domain-containing protein 8

2

1

High-throughput

0.611

High

608752

DDX5
Probable ATP-dependent RNA helicase DDX5

2

3

High-throughput

0.611

High

1361812

ZCH14
Zinc finger CCHC domain-containing protein 14

2

2

High-throughput

0.611

High

561389

TDGF1
Protein Cripto

3

4

High-throughput

0.609

High

567986

PRG2
Bone marrow proteoglycan

3

9

High-throughput

0.609

High

1418245

RM04
Large ribosomal subunit protein uL4m

3

4

High-throughput

0.609

High

1380538

PIGT
GPI-anchor transamidase component PIGT

3

4

High-throughput

0.604

High

1392994

CC120
Coiled-coil domain-containing protein 120

3

4

High-throughput

0.604

High

1436211

INSL6
Insulin-like peptide INSL6

3

4

High-throughput

0.604

High

1408511

GDF15
Growth/differentiation factor 15

2

6

High-throughput

0.601

High

1436196

EMIL3
EMILIN-3

2

5

High-throughput

0.601

High

856926

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.586

High

1433308

WNK1
Serine/threonine-protein kinase WNK1

2

6

Small-scale

0.584

High

278753

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

3

High-throughput

0.574

High

1395080

JPH4
Junctophilin-4

2

2

High-throughput

0.574

High

1436208

PRG3
Proteoglycan 3

2

9

High-throughput

0.574

High

1161803

CDKN3
Cyclin-dependent kinase inhibitor 3

2

0

Small-scale

0.559

High

409611

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

3

High-throughput

0.558

High

1430506

RM18
Large ribosomal subunit protein uL18m

2

4

High-throughput

0.549

High

894171

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

169318

LECT2
Leukocyte cell-derived chemotaxin-2

1

3

High-throughput

0.536

High

270275

MTG16
Protein CBFA2T3

1

3

High-throughput

0.536

High

568592

TNNT1
Troponin T, slow skeletal muscle

1

2

High-throughput

0.536

High

648233

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.536

High

721739

GCH1
GTP cyclohydrolase 1

1

3

High-throughput

0.536

High

872753

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.536

High

1250858

CRDL2
Chordin-like protein 2

1

3

High-throughput

0.536

High

1335248

KCTD6
BTB/POZ domain-containing protein KCTD6

1

5

High-throughput

0.536

High

1436193

E41L5
Band 4.1-like protein 5

1

2

High-throughput

0.536

High

1436201

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

5

High-throughput

0.536

High

1096225

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.515

High

1365155

MAML1
Mastermind-like protein 1

1

0

High-throughput

0.513

High

181942

SMAD9
Mothers against decapentaplegic homolog 9

1

4

High-throughput

0.508

High

423188

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

927553

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

139082

LAD1
Ladinin-1

1

2

High-throughput

0.489

High

316693

LY6H
Lymphocyte antigen 6H

1

2

High-throughput

0.489

High

377295

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

4

High-throughput

0.489

High

477345

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

3

High-throughput

0.489

High

652676

GNLY
Granulysin

1

4

High-throughput

0.489

High

1179860

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1206433

EFHC2
EF-hand domain-containing family member C2

1

3

High-throughput

0.489

High

1340132

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

2

High-throughput

0.489

High

1369134

COR2A
Coronin-2A

1

3

High-throughput

0.489

High

1389207

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.489

High

1428799

WN10A
Protein Wnt-10a

1

4

High-throughput

0.489

High

1436192

SPON1
Spondin-1

1

4

High-throughput

0.489

High

1436203

MRM2
rRNA methyltransferase 2, mitochondrial

1

2

High-throughput

0.489

High

1436209

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

2

High-throughput

0.489

High

154753

ARI1A
AT-rich interactive domain-containing protein 1A

1

1

High-throughput

0.479

High

162698

ANM5
Protein arginine N-methyltransferase 5

1

2

High-throughput

0.479

High

226882

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.479

High

246954

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

326043

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.479

High

344019

HS74L
Heat shock 70 kDa protein 4L

1

5

High-throughput

0.479

High

376909

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.479

High

402685

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

437345

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

446048

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

480388

MMP7
Matrilysin

1

4

High-throughput

0.479

High

681722

PSA4
Proteasome subunit alpha type-4

1

2

High-throughput

0.479

High

756350

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.479

High

810386

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

861294

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

881314

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

887592

PSB3
Proteasome subunit beta type-3

1

1

High-throughput

0.479

High

887727

PSB2
Proteasome subunit beta type-2

1

2

High-throughput

0.479

High

907581

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

931118

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.479

High

938286

SEC13
Protein SEC13 homolog

1

1

High-throughput

0.479

High

956008

RAB8A
Ras-related protein Rab-8A

1

4

High-throughput

0.479

High

960567

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

978730

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

984993

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

1008355

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

1054647

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.479

High

1098597

GPS2
G protein pathway suppressor 2

1

2

High-throughput

0.479

High

1115436

CUL4B
Cullin-4B

1

3

High-throughput

0.479

High

1118163

DX39B
Spliceosome RNA helicase DDX39B

1

4

High-throughput

0.479

High

1134537

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

High-throughput

0.479

High

1135587

K2C72
Keratin, type II cytoskeletal 72

1

1

High-throughput

0.479

High

1152045

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

8

High-throughput

0.479

High

1163760

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

8

High-throughput

0.479

High

1168893

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

17

High-throughput

0.479

High

1212855

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.479

High

1270334

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

1272434

GET4
Golgi to ER traffic protein 4 homolog

1

1

High-throughput

0.479

High

1280505

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1287990

PB1
Protein polybromo-1

1

1

High-throughput

0.479

High

1311650

KIBRA
Protein KIBRA

1

6

Small-scale

0.479

High

1365236

HS105
Heat shock protein 105 kDa

1

5

High-throughput

0.479

High

1394707

WNK4
Serine/threonine-protein kinase WNK4

1

6

Small-scale

0.479

High

1405025

NEUR1
Sialidase-1

1

1

High-throughput

0.479

High

1408331

PKP2
Plakophilin-2

1

6

High-throughput

0.479

High

1414329

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

12

High-throughput

0.479

High

1433906

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1435294

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1436206

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

1436207

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.479

High

1436210

PRC2C
Protein PRRC2C

1

1

High-throughput

0.479

High

64121

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

128323

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.458

High

160623

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

320061

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

347334

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

443524

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

539257

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

705843

AMPL
Cytosol aminopeptidase

1

0

High-throughput

0.458

High

723093

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

910690

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.458

High

936860

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

937345

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.458

High

944564

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

945861

EPIPL
Epiplakin

1

0

High-throughput

0.458

High

969056

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.458

High

969691

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

979247

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1083312

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.458

High

1108161

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1137268

CND1
Condensin complex subunit 1

1

0

High-throughput

0.458

High

1157934

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

1162738

QPCT
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.458

High

1192110

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.458

High

1213019

SKT
Sickle tail protein homolog

1

0

High-throughput

0.458

High

1271673

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.458

High

1277787

MYH14
Myosin-14

1

0

High-throughput

0.458

High

1281613

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1323157

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

1404117

PSB7
Proteasome subunit beta type-7

1

0

High-throughput

0.458

High

1404583

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

1436199

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1436204

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1436195

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

872026

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

3

High-throughput

0.445

High

1181501

EMAL3
Echinoderm microtubule-associated protein-like 3

1

3

High-throughput

0.445

High

1335385

CAMKV
CaM kinase-like vesicle-associated protein

1

2

High-throughput

0.445

High

1381863

H2B1A
Histone H2B type 1-A

1

1

High-throughput

0.445

High

1420808

ZCHC2
Zinc finger CCHC domain-containing protein 2

1

2

High-throughput

0.445

High

390764

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

814926

GDNF
Glial cell line-derived neurotrophic factor

1

2

High-throughput

0.437

High

1063872

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.437

High

1194796

GRPL2
GLIPR1-like protein 2

1

3

High-throughput

0.437

High

1393184

SFRP2
Secreted frizzled-related protein 2

1

3

High-throughput

0.437

High

1393499

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

High-throughput

0.437

High

1412332

GDAH
Guanidino acid hydrolase, mitochondrial

1

2

High-throughput

0.437

High

63778

KRBA1
Protein KRBA1

1

1

High-throughput

0.407

High

615199

PACA
Pituitary adenylate cyclase-activating polypeptide

1

3

High-throughput

0.407

High

1331857

SYT2
Synaptotagmin-2

1

4

High-throughput

0.407

High

1402424

HPLN3
Hyaluronan and proteoglycan link protein 3

1

4

High-throughput

0.407

High

1372167

SBP2L
Selenocysteine insertion sequence-binding protein 2-like

1

0

High-throughput

0.279

Low

301706

WFS1
Wolframin

1

0

High-throughput

0.268

Low

891038

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.268

Low

1410460

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

1233488

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1436198

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025