Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH
Interactor 2: TOLIP (Q9H0E2)
Toll-interacting protein
Gene: TOLLIP
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.70 | 1.00 | 0.839 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33545068, 21903422, unassigned3799 |
| Identification Methods | proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C2~C2 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006954 - inflammatory response GO:0032991 - protein-containing complex and 2 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
