HitPredict

Interactor 1: SIKE1 (Q9BRV8)
Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)
Gene: SIKE1

Interactor 2: STRN4 (Q9NRL3)
Striatin-4 (Zinedin)
Gene: STRN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	26496610, 18782753, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030674 - protein-macromolecule adaptor activity GO:0035331 - negative regulation of hippo signaling GO:0090443 - FAR/SIN/STRIPAK complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 207 Hs			1 753
+	Hs
		1448642 FGOP2_HUMAN (1-203): 1.23e-47: 158: 43.50		STRN4_HUMAN (1-753): 0: 551: 100.00
+	Hs
		1092923 SIKE1_HUMAN (1-207): 1.94e-70: 215: 100.00		STRN3_HUMAN (2-753): 1.46e-147: 452: 49.63
+	Hs
		228624 SIKE1_HUMAN (1-207): 1.94e-70: 215: 100.00		STRN_HUMAN (36-753): 7e-137: 424: 47.92
+	Hs
		1092936 FGOP2_HUMAN (1-203): 1.23e-47: 158: 43.50		STRN3_HUMAN (2-753): 1.46e-147: 452: 49.63
+	Hs
		228638 FGOP2_HUMAN (1-203): 1.23e-47: 158: 43.50		STRN_HUMAN (36-753): 7e-137: 424: 47.92
+	Dm
		92294 FGOP2_DROME (4-189): 6.54e-55: 178: 30.00		D3DML3_DROME (56-753): 4.23e-126: 395: 43.04