Protein: SIKE1
Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)

Gene: SIKE1
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q9BRV8

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0030674 - protein-macromolecule adaptor activity
GO:0031267 - small GTPase binding
GO:0035331 - negative regulation of hippo signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1411929

FGOP2
FGFR1 oncogene partner 2

3

1

High-throughput

0.871

High

1092923

STRN3
Striatin-3

8

7

High-throughput

0.754

High

717967

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

6

3

High-throughput

0.737

High

228624

STRN
Striatin

5

7

High-throughput

0.722

High

977575

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

5

3

High-throughput

0.722

High

1135374

SLMAP
Sarcolemmal membrane-associated protein

5

8

High-throughput

0.722

High

1411939

PHOCN
MOB-like protein phocein

4

2

High-throughput

0.706

High

994351

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

3

High-throughput

0.704

High

1411932

STK26
Serine/threonine-protein kinase 26

4

13

High-throughput

0.699

High

1411941

STK24
Serine/threonine-protein kinase 24

4

13

High-throughput

0.699

High

138866

STK25
Serine/threonine-protein kinase 25

4

13

High-throughput

0.691

High

1411927

STRN4
Striatin-4

3

6

High-throughput

0.678

High

1217352

STRP1
Striatin-interacting protein 1

3

4

High-throughput

0.675

High

1411924

PDC10
Programmed cell death protein 10

3

1

High-throughput

0.675

High

1411937

STRP2
Striatin-interacting protein 2

3

4

High-throughput

0.675

High

1411938

T3JAM
TRAF3-interacting JNK-activating modulator

3

7

High-throughput

0.671

High

969041

PRS8
26S proteasome regulatory subunit 8

2

1

High-throughput

0.628

High

1411936

TNIK
TRAF2 and NCK-interacting protein kinase

2

16

High-throughput

0.611

High

1198845

ZC21C
Zinc finger C2HC domain-containing protein 1C

3

1

High-throughput

0.607

High

821192

TXLNA
Alpha-taxilin

2

1

High-throughput

0.606

High

1326639

KIF2B
Kinesin-like protein KIF2B

2

0

High-throughput

0.602

High

1411928

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.602

High

718169

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

3

High-throughput

0.601

High

1271989

CENPQ
Centromere protein Q

2

0

High-throughput

0.580

High

1392870

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1411935

SCOC
Short coiled-coil protein

2

0

High-throughput

0.580

High

1411923

SIKE1
Suppressor of IKBKE 1

1

1

High-throughput

0.575

High

622672

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

1

High-throughput

0.574

High

1325252

TXLNB
Beta-taxilin

2

1

High-throughput

0.553

High

936618

ELL
RNA polymerase II elongation factor ELL

1

1

High-throughput

0.536

High

1226003

ICE2
Little elongation complex subunit 2

1

1

High-throughput

0.536

High

1277066

CC186
Coiled-coil domain-containing protein 186

1

1

High-throughput

0.536

High

1292465

RASF3
Ras association domain-containing protein 3

1

2

High-throughput

0.536

High

1411925

RABE2
Rab GTPase-binding effector protein 2

1

2

High-throughput

0.536

High

1411930

ABI2
Abl interactor 2

1

2

High-throughput

0.536

High

445249

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

883135

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.513

High

1313689

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1382576

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.513

High

1405798

TTC1
Tetratricopeptide repeat protein 1

1

0

High-throughput

0.513

High

1411940

MRCKB
Serine/threonine-protein kinase MRCK beta

1

0

High-throughput

0.513

High

949285

MYPR
Myelin proteolipid protein

1

1

High-throughput

0.489

High

1217079

RAIN
Ras-interacting protein 1

1

1

High-throughput

0.489

High

1287727

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

1

High-throughput

0.489

High

1411933

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1411934

TBK1
Serine/threonine-protein kinase TBK1

1

1

Small-scale

0.479

High

895015

EMD
Emerin

1

0

Small-scale

0.458

High

1398825

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.458

High

76371

B4DR80
non-specific serine/threonine protein kinase

1

13

High-throughput

0.445

High

348191

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

15

High-throughput

0.437

High

1123399

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.437

High

116547

H7C5G9
Sarcolemmal membrane-associated protein

1

7

High-throughput

0.407

High

117043

J3KS15
Large ribosomal subunit protein mL62

1

1

High-throughput

0.407

High

1205208

NHSL2
NHS-like protein 2

1

2

High-throughput

0.407

High

286718

STX11
Syntaxin-11

4

0

High-throughput

0.364

High

1330515

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

0

High-throughput

0.328

High

216192

MTG8R
Protein CBFA2T2

2

0

High-throughput

0.316

High

1006296

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.316

High

846827

BTD
Biotinidase

1

0

High-throughput

0.279

Low

1250880

ZY11A
Protein zyg-11 homolog A

1

0

High-throughput

0.279

Low

1324658

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

0

High-throughput

0.279

Low

1411926

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

0

High-throughput

0.279

Low

1411931

DAPLE
Protein Daple

1

0

High-throughput

0.279

Low

353537

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025