HitPredict

Interactor 1: RRAGC (Q9HB90)
Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)
Gene: RRAGC

Interactor 2: LTOR2 (Q9Y2Q5)
Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)
Gene: LAMTOR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	20381137, 25567906, 33961781, 25561175, unassigned3799, 22980980
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0008104 - intracellular protein localization GO:0060090 - molecular adaptor activity GO:0071230 - cellular response to amino acid stimulus GO:1904263 - positive regulation of TORC1 signaling and 1 others more... GO:1990877 - FNIP-folliculin RagC/D GAP
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 125
+	Hs
		1447135 RRAGD_HUMAN (25-396): 0: 527: 80.91		LTOR2_HUMAN (1-125): 1.94e-61: 185: 100.00
+	Hs
		1272167 RRAGA_HUMAN (53-284): 3.28e-105: 314: 26.27		LTOR2_HUMAN (1-125): 1.94e-61: 185: 100.00
+	Hs
		1219792 RRAGB_HUMAN (43-284): 9.95e-104: 313: 24.09		LTOR2_HUMAN (1-125): 1.94e-61: 185: 100.00