HitPredict

Interactor 1: PRP19 (O14011)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: CWF14 (O74772)
Pre-mRNA-splicing factor cwf14 (Complexed with cdc5 protein 14)
Gene: CWF14

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24874881, 21386897
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0005681 - spliceosomal complex GO:0071014 - post-mRNA release spliceosomal complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 488 Sp			1 146
+	Hs
		782183 PRP19_HUMAN (1-487): 1.28e-115: 351: 25.69		BUD31_HUMAN (1-143): 1.03e-83: 243: 59.72
+	Sc
		629362 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		BUD31_YEAST (1-146): 5.93e-74: 219: 54.78
+	Hs
		782138 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		BUD31_HUMAN (1-143): 1.03e-83: 243: 59.72