HitPredict

Interactor 1: PRP19 (O14011)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: YK99 (Q9HE06)
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09 (EC 3.6.4.13) (DEAH-box helicase C20H4.09)
Gene: SPAC20H4.09

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36361590, 21386897
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~DEAD
Common GO terms	GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Sp			1 647
+	Hs
		1055513 PRP19_HUMAN (1-487): 1.28e-115: 351: 25.69		DHX8_HUMAN (7-645): 0: 723: 39.94
+	Sp
		144075 PRP19_SCHPO (1-488): 4.18e-104: 321: 96.95		PRP22_SCHPO (10-644): 0: 697: 38.72
+	Sp
		144117 PRP19_SCHPO (1-488): 4.18e-104: 321: 96.95		CDC28_SCHPO (15-642): 0: 683: 39.56
+	Hs
		1332149 PRP19_HUMAN (1-487): 1.28e-115: 351: 25.69		DHX35_HUMAN (18-644): 0: 650: 40.31
+	Sp
		144124 PRP19_SCHPO (1-488): 4.18e-104: 321: 96.95		PRP16_SCHPO (14-643): 0: 680: 37.54
+	Sp
		144077 PRP19_SCHPO (1-488): 4.18e-104: 321: 96.95		DHX15_SCHPO (2-644): 0: 678: 37.65
+	Sc
		589417 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		PRP2_YEAST (5-644): 0: 756: 33.78
+	Zm
		18259 A0A1D6J4G2_MAIZE (72-487): 1.4e-51: 185: 14.79		A0A1D6H4I5_MAIZE (18-645): 0: 733: 38.73
+	Hs
		1055447 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		DHX8_HUMAN (7-645): 0: 723: 39.94
+	Sc
		622300 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		PRP22_YEAST (4-647): 0: 677: 38.19
+	Sc
		692324 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		PRP43_YEAST (2-645): 0: 662: 38.73
+	Hs
		1268324 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		PRP16_HUMAN (7-647): 0: 701: 35.44
+	Sc
		589056 PRP4_YEAST (174-476): 8.43e-29: 120: 21.62		PRP2_YEAST (5-644): 0: 756: 33.78
+	Hs
		224827 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		DHX16_HUMAN (20-647): 0: 693: 38.15
+	Hs
		195393 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		DHX15_HUMAN (4-645): 0: 699: 37.86
+	Sc
		554207 PRP19_YEAST (1-451): 3.74e-64: 217: 19.75		PRP16_YEAST (22-643): 0: 615: 37.50
+	Hs
		1288306 SNR40_HUMAN (148-398): 1.71e-49: 175: 9.24		DHX35_HUMAN (18-644): 0: 650: 40.31
+	Hs
		209435 PLRG1_HUMAN (128-306): 1.31e-09: 62.3: 7.80		DHX8_HUMAN (7-645): 0: 723: 39.94
+	Hs
		197089 PRP4_HUMAN (146-323): 2.21e-25: 110: 6.08		DHX33_HUMAN (4-646): 0: 632: 35.98
+	Hs
		903167 WDR5_HUMAN (130-360): 3.43e-35: 135: 8.47		DHX9_HUMAN (1-646): 0: 577: 25.45