Protein: BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)

Gene: BUB1
Organism: Homo sapiens
Interactions: 137
UniProt ID: O43683

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

224058

BUB3
Mitotic checkpoint protein BUB3

10

13

Small-scale

0.978

High

224061

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

8

20

Small-scale

0.968

High

224102

RAE1L
mRNA export factor RAE1

4

12

Small-scale

0.895

High

224143

KNL1
Outer kinetochore KNL1 complex subunit KNL1

11

1

Small-scale

0.758

High

224110

CDC20
Cell division cycle protein 20 homolog

12

17

Small-scale

0.758

High

224167

MIS12
Protein MIS12 homolog

6

1

Small-scale

0.730

High

224097

PLK1
Serine/threonine-protein kinase PLK1

1

19

Small-scale

0.724

High

224066

ZN189
Zinc finger protein 189

1

1

High-throughput

0.698

High

224074

RASH
GTPase HRas

1

7

High-throughput

0.698

High

224083

RASA1
Ras GTPase-activating protein 1

1

16

High-throughput

0.698

High

224090

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

High-throughput

0.698

High

224095

CDK8
Cyclin-dependent kinase 8

1

16

High-throughput

0.698

High

224106

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.698

High

224155

CANB2
Calcineurin subunit B type 2

1

18

High-throughput

0.698

High

224163

TBD2A
TBC1 domain family member 2A

1

14

High-throughput

0.698

High

224182

ZN510
Zinc finger protein 510

1

1

High-throughput

0.698

High

224070

ARI2
E3 ubiquitin-protein ligase ARIH2

4

8

High-throughput

0.692

High

224063

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

6

High-throughput

0.691

High

224085

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.691

High

224151

SEH1
Nucleoporin SEH1

1

4

High-throughput

0.691

High

224162

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.691

High

224177

APC4
Anaphase-promoting complex subunit 4

1

2

High-throughput

0.691

High

163863

NDC80
Kinetochore protein NDC80 homolog

3

18

High-throughput

0.671

High

224099

MLF1
Myeloid leukemia factor 1

3

1

High-throughput

0.667

High

224057

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

18

High-throughput

0.665

High

224065

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.663

High

224067

UBR5
E3 ubiquitin-protein ligase UBR5

3

20

Small-scale

0.650

High

224077

CDK1
Cyclin-dependent kinase 1

1

10

Small-scale

0.647

High

224080

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.647

High

224096

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

3

High-throughput

0.628

High

224112

CDC16
Cell division cycle protein 16 homolog

2

17

High-throughput

0.628

High

224129

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

1

High-throughput

0.625

High

224148

COR2A
Coronin-2A

1

6

High-throughput

0.625

High

224154

NSL1
Kinetochore-associated protein NSL1 homolog

3

0

Small-scale

0.622

High

224068

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

2

1

High-throughput

0.621

High

224087

MK03
Mitogen-activated protein kinase 3

1

17

High-throughput

0.621

High

224094

CRK
Adapter molecule crk

2

20

High-throughput

0.619

High

224114

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

14

High-throughput

0.618

High

224115

SQSTM
Sequestosome-1

1

12

High-throughput

0.618

High

224136

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

224149

RBPMS
RNA-binding protein with multiple splicing

1

1

High-throughput

0.618

High

224178

ANC2
Anaphase-promoting complex subunit 2

1

15

High-throughput

0.618

High

224109

BPTF
Nucleosome-remodeling factor subunit BPTF

2

11

High-throughput

0.611

High

224116

HDAC1
Histone deacetylase 1

2

9

Small-scale

0.611

High

224131

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

224124

MAPK3
MAP kinase-activated protein kinase 3

1

18

High-throughput

0.590

High

224139

NKAP
NF-kappa-B-activating protein

2

2

Small-scale

0.584

High

76696

B4E3T4
HCG2043421, isoform CRA_c

1

1

High-throughput

0.575

High

224059

PRKY
Putative serine/threonine-protein kinase PRKY

1

20

High-throughput

0.575

High

224113

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

9

Small-scale

0.563

High

224086

APC
Adenomatous polyposis coli protein

1

8

Small-scale

0.561

High

224166

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

8

High-throughput

0.561

High

144120

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

3

High-throughput

0.541

High

159296

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

High-throughput

0.541

High

224062

CC14B
Dual specificity protein phosphatase CDC14B

1

10

High-throughput

0.541

High

224075

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.541

High

224076

ALDOB
Fructose-bisphosphate aldolase B

1

2

High-throughput

0.541

High

224078

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.541

High

224082

IBP3
Insulin-like growth factor-binding protein 3

1

1

High-throughput

0.541

High

224084

XPA
DNA repair protein complementing XP-A cells

1

1

High-throughput

0.541

High

224088

TMOD1
Tropomodulin-1

1

3

High-throughput

0.541

High

224089

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.541

High

224092

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

2

High-throughput

0.541

High

224098

STX17
Syntaxin-17

1

1

High-throughput

0.541

High

224100

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.541

High

224101

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

18

High-throughput

0.541

High

224118

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

1

High-throughput

0.541

High

224119

CYLC2
Cylicin-2

1

1

High-throughput

0.541

High

224122

SMAD1
Mothers against decapentaplegic homolog 1

1

2

High-throughput

0.541

High

224130

SFRP4
Secreted frizzled-related protein 4

1

3

High-throughput

0.541

High

224147

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

7

High-throughput

0.541

High

224161

HEMGN
Hemogen

1

1

High-throughput

0.541

High

224172

SIAS
N-acetylneuraminate-9-phosphate synthase

1

1

High-throughput

0.541

High

224176

LEF1
Lymphoid enhancer-binding factor 1

1

9

High-throughput

0.541

High

224072

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

224093

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.536

High

224117

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

224121

PLEC
Plectin

1

5

High-throughput

0.536

High

224125

KI26B
Kinesin-like protein KIF26B

1

9

High-throughput

0.536

High

224157

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.536

High

224159

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

224173

CARF
CDKN2A-interacting protein

1

1

High-throughput

0.536

High

224104

FANCC
Fanconi anemia group C protein

1

0

High-throughput

0.518

High

224164

NUF2
Kinetochore protein Nuf2

1

8

High-throughput

0.515

High

224169

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.515

High

224171

SPC25
Kinetochore protein Spc25

1

1

High-throughput

0.515

High

224105

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.513

High

224181

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.513

High

224168

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

8

High-throughput

0.501

High

224183

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

224138

TEFF1
Tomoregulin-1

1

5

High-throughput

0.494

High

224140

AMPO
Aminopeptidase O

1

2

High-throughput

0.494

High

224144

TDRD7
Tudor domain-containing protein 7

1

3

High-throughput

0.494

High

224153

SFRP2
Secreted frizzled-related protein 2

1

3

High-throughput

0.494

High

224156

RDH12
Retinol dehydrogenase 12

1

3

High-throughput

0.494

High

224160

TRMO
tRNA

1

1

High-throughput

0.494

High

224142

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.493

High

224185

TX264
Testis-expressed protein 264

1

0

High-throughput

0.493

High

224079

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

1

High-throughput

0.489

High

224146

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.481

High

224071

SVIL
Supervillin

1

3

Small-scale

0.481

High

224060

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

224069

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

224081

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

224091

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.479

High

224107

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.479

High

224111

TP53B
TP53-binding protein 1

1

4

Small-scale

0.479

High

224123

ZYX
Zyxin

1

20

High-throughput

0.479

High

224128

NKAPL
NKAP-like protein

1

2

High-throughput

0.479

High

224132

PMF1
Polyamine-modulated factor 1

1

1

High-throughput

0.479

High

224150

PF21A
PHD finger protein 21A

1

4

High-throughput

0.479

High

224158

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.479

High

224170

FA83D
Protein FAM83D

1

1

High-throughput

0.479

High

224175

XPO7
Exportin-7

1

9

High-throughput

0.479

High

224179

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

224180

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

224127

RABL6
Rab-like protein 6

1

0

High-throughput

0.458

High

224145

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.458

High

126027

AP3B1
AP-3 complex subunit beta-1

1

10

Small-scale

0.457

High

224108

AP1B1
AP-1 complex subunit beta-1

1

10

Small-scale

0.457

High

224184

AP4B1
AP-4 complex subunit beta-1

1

12

Small-scale

0.457

High

224073

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.445

High

224120

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.445

High

76607

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

124159

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

224133

FBX42
F-box only protein 42

1

8

High-throughput

0.437

High

224174

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

224103

BAT1
b(0,+)-type amino acid transporter 1

1

3

High-throughput

0.407

High

224135

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

2

0

High-throughput

0.328

High

224064

CATL2
Cathepsin L2

1

0

High-throughput

0.282

High

224137

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.282

High

224152

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.282

High

224126

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

224141

PRLD2
PRELI domain-containing protein 2

1

0

High-throughput

0.279

Low

224165

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

0

High-throughput

0.279

Low

224134

CF161
Cilia- and flagella-associated protein 161

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025