HitPredict

Interactor 1: POP2 (O14170)
WD repeat-containing protein pop2 (Proteolysis factor sud1)
Gene: POP2

Interactor 2: POP1 (P87060)
WD repeat-containing protein pop1 (WD repeat-containing protein ste16)
Gene: POP1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	9990507, 12167173, 10209119
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0019005 - SCF ubiquitin ligase complex GO:0030674 - protein-macromolecule adaptor activity GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043224 - nuclear SCF ubiquitin ligase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 703 Sp			1 775
+	Sp
		953233 POP1_SCHPO (166-702): 7.94e-103: 333: 35.92		POP1_SCHPO (1-775): 0: 613: 98.84
+	Sp
		144895 POP2_SCHPO (1-703): 0: 543: 100.00		POP2_SCHPO (71-774): 2.13e-120: 379: 31.29
+	Ce
		1274778 SEL10_CAEEL (432-700): 5.63e-59: 211: 23.83		SEL10_CAEEL (556-766): 4.23e-56: 204: 26.03
+	Hs
		1281292 FBXW7_HUMAN (529-700): 3.93e-43: 168: 24.44		FBXW7_HUMAN (472-767): 8.18e-61: 219: 24.50
+	Hs
		793026 LIS1_HUMAN (486-699): 1.72e-58: 205: 18.60		KTNB1_HUMAN (395-651): 3.21e-39: 156: 19.70
+	Mm
		925836 LIS1_MOUSE (486-699): 1.25e-58: 205: 18.60		LIS1_MOUSE (124-540): 1.27e-38: 150: 9.55
+	Hs
		792935 LIS1_HUMAN (486-699): 1.72e-58: 205: 18.60		LIS1_HUMAN (202-540): 4.28e-38: 149: 9.95
+	Hs
		903349 WDR5B_HUMAN (476-700): 4e-63: 215: 27.35		WDR5_HUMAN (648-764): 1.22e-32: 131: 24.19
+	Hs
		792949 LIS1_HUMAN (486-699): 1.72e-58: 205: 18.60		WDR5_HUMAN (648-764): 1.22e-32: 131: 24.19
+	Hs
		903551 WDR5_HUMAN (189-473): 8.87e-46: 167: 11.95		NLE1_HUMAN (650-766): 2.36e-32: 133: 26.15
+	Hs
		903418 FBXW7_HUMAN (529-700): 3.93e-43: 168: 24.44		WDR5_HUMAN (648-764): 1.22e-32: 131: 24.19
+	Hs
		903077 WDR5_HUMAN (189-473): 8.87e-46: 167: 11.95		WDR5_HUMAN (648-764): 1.22e-32: 131: 24.19
+	Hs
		903174 WDR5_HUMAN (189-473): 8.87e-46: 167: 11.95		TBL3_HUMAN (311-517): 2.34e-29: 127: 11.56
+	Hs
		1281468 FBXW7_HUMAN (529-700): 3.93e-43: 168: 24.44		FBXW2_HUMAN (613-764): 2.41e-21: 99.8: 15.39
+	Hs
		209416 WDR5_HUMAN (189-473): 8.87e-46: 167: 11.95		PLRG1_HUMAN (571-730): 3.61e-14: 77.8: 28.40
+	Sc
		630844 NLE1_YEAST (221-532): 5.36e-46: 173: 13.70		NLE1_YEAST (688-766): 6.55e-12: 70.9: 11.91
+	Sc
		431134 MET30_YEAST (533-700): 1.51e-41: 162: 25.73		CDC4_YEAST (696-773): 1.88e-10: 66.6: 13.10