HitPredict

Interactor 1: BHE40 (O14503)
Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)
Gene: BHLHE40

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

The method score is based on:

Property	Details
Experiments	10737769, 22723347
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm and 5 others more... GO:0006357 - regulation of transcription by RNA polymerase II GO:0032922 - circadian regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070888 - E-box binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	412
Hs

1	482

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024