Protein: ARNT
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)

Gene: ARNT
Organism: Homo sapiens
Interactions: 214
UniProt ID: P27540

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

649123

HIF1A
Hypoxia-inducible factor 1-alpha

63

20

Small-scale

0.997

High

649052

AHR
Aryl hydrocarbon receptor

29

20

Small-scale

0.992

High

649150

EPAS1
Endothelial PAS domain-containing protein 1

16

20

Small-scale

0.987

High

649106

SIM2
Single-minded homolog 2

7

20

Small-scale

0.970

High

649033

ARNT
Aryl hydrocarbon receptor nuclear translocator

4

20

Small-scale

0.875

High

649175

HIF3A
Hypoxia-inducible factor 3-alpha

3

20

Small-scale

0.855

High

649084

SIM1
Single-minded homolog 1

3

20

Small-scale

0.849

High

649148

NPAS1
Neuronal PAS domain-containing protein 1

2

20

High-throughput

0.811

High

649117

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.800

High

649131

NPAS4
Neuronal PAS domain-containing protein 4

2

20

Small-scale

0.767

High

649119

NCOA1
Nuclear receptor coactivator 1

1

20

Small-scale

0.740

High

69415

AHRR
Aryl hydrocarbon receptor repressor

1

20

Small-scale

0.713

High

649126

FOXR2
Forkhead box protein R2

4

7

High-throughput

0.699

High

649132

NPAS3
Neuronal PAS domain-containing protein 3

1

20

High-throughput

0.691

High

649149

NPAS2
Neuronal PAS domain-containing protein 2

1

20

Small-scale

0.680

High

503482

HSP7C
Heat shock cognate 71 kDa protein

3

8

High-throughput

0.667

High

345984

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.647

High

649179

TACC3
Transforming acidic coiled-coil-containing protein 3

2

10

Small-scale

0.643

High

649042

AKT1
RAC-alpha serine/threonine-protein kinase

2

7

Small-scale

0.629

High

649064

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

14

Small-scale

0.629

High

649044

GLYC
Serine hydroxymethyltransferase, cytosolic

2

1

High-throughput

0.628

High

649168

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

2

11

Small-scale

0.625

High

181499

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.621

High

649169

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

7

Small-scale

0.621

High

649177

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

7

Small-scale

0.621

High

649159

EGLN3
Prolyl hydroxylase EGLN3

2

14

Small-scale

0.611

High

649165

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

2

1

Small-scale

0.611

High

649118

TRIPB
Thyroid receptor-interacting protein 11

3

9

Small-scale

0.609

High

369025

ESR1
Estrogen receptor

2

20

Small-scale

0.602

High

649151

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.602

High

649158

CIAO3
Cytosolic iron-sulfur assembly component 3

2

0

High-throughput

0.602

High

386142

P53
Cellular tumor antigen p53

2

7

High-throughput

0.595

High

649038

PML
Protein PML

2

11

Small-scale

0.595

High

649045

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

649093

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

649102

CUL2
Cullin-2

2

7

Small-scale

0.584

High

649115

ELOB
Elongin-B

2

2

Small-scale

0.584

High

649156

EGLN1
Egl nine homolog 1

2

14

Small-scale

0.584

High

649056

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.573

High

649137

NCOA7
Nuclear receptor coactivator 7

1

1

Small-scale

0.569

High

649178

NCOR2
Nuclear receptor corepressor 2

1

7

Small-scale

0.569

High

649054

BRCA1
Breast cancer type 1 susceptibility protein

1

7

Small-scale

0.561

High

649067

PAXI
Paxillin

1

4

High-throughput

0.553

High

649146

STRBP
Spermatid perinuclear RNA-binding protein

1

3

High-throughput

0.541

High

649153

MTA3
Metastasis-associated protein MTA3

1

6

High-throughput

0.541

High

602802

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.537

High

649058

CASP3
Caspase-3

1

3

Small-scale

0.536

High

649074

CASP9
Caspase-9

1

3

Small-scale

0.536

High

175956

FOXN1
Forkhead box protein N1

1

8

High-throughput

0.536

High

556785

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

649072

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

649098

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

649138

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

3

High-throughput

0.536

High

649152

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.536

High

649157

SHRPN
Sharpin

1

1

High-throughput

0.536

High

649170

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.536

High

267124

GEMI
Geminin

1

0

High-throughput

0.518

High

649166

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.518

High

171365

SMAD9
Mothers against decapentaplegic homolog 9

1

6

High-throughput

0.508

High

118694

AIP
AH receptor-interacting protein

1

11

Small-scale

0.501

High

131380

IMA4
Importin subunit alpha-4

1

14

Small-scale

0.501

High

168619

IMA6
Importin subunit alpha-6

1

14

Small-scale

0.501

High

238633

IMA7
Importin subunit alpha-7

1

14

Small-scale

0.501

High

373718

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.501

High

383626

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.501

High

434958

SP1
Transcription factor Sp1

1

8

Small-scale

0.501

High

515336

CDK4
Cyclin-dependent kinase 4

1

8

High-throughput

0.501

High

534062

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.501

High

536119

HGF
Hepatocyte growth factor

1

3

High-throughput

0.501

High

557039

PGFRA
Platelet-derived growth factor receptor alpha

1

4

High-throughput

0.501

High

649040

CCND2
G1/S-specific cyclin-D2

1

3

High-throughput

0.501

High

649046

MERL
Merlin

1

3

High-throughput

0.501

High

649048

T2FA
General transcription factor IIF subunit 1

1

3

Small-scale

0.501

High

649059

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

7

High-throughput

0.501

High

649060

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

6

High-throughput

0.501

High

649061

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

7

High-throughput

0.501

High

649071

IMA5
Importin subunit alpha-5

1

14

Small-scale

0.501

High

649086

CDK6
Cyclin-dependent kinase 6

1

8

High-throughput

0.501

High

649089

TF65
Transcription factor p65

1

10

High-throughput

0.501

High

649095

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

13

High-throughput

0.501

High

649105

TBB2A
Tubulin beta-2A chain

1

4

Small-scale

0.501

High

649112

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.501

High

649116

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

649120

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.501

High

649122

MK14
Mitogen-activated protein kinase 14

1

4

High-throughput

0.501

High

649134

GLIS1
Zinc finger protein GLIS1

1

4

High-throughput

0.501

High

649155

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

649164

LATS2
Serine/threonine-protein kinase LATS2

1

9

High-throughput

0.501

High

649171

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.501

High

323600

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.489

High

361207

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.489

High

398326

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.489

High

648460

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

649104

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

2

High-throughput

0.481

High

624542

CCNE1
G1/S-specific cyclin-E1

1

0

High-throughput

0.480

High

649109

BECN1
Beclin-1

1

0

High-throughput

0.480

High

117596

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.479

High

197663

CRX
Cone-rod homeobox protein

1

7

High-throughput

0.479

High

214507

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.479

High

229315

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

9

High-throughput

0.479

High

230207

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

3

High-throughput

0.479

High

240527

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

1

High-throughput

0.479

High

243300

DNJA2
DnaJ homolog subfamily A member 2

1

12

High-throughput

0.479

High

278229

PIAS2
E3 SUMO-protein ligase PIAS2

1

4

Small-scale

0.479

High

318576

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.479

High

319723

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

349894

RASK
GTPase KRas

1

3

High-throughput

0.479

High

388240

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.479

High

391336

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.479

High

396685

S10A8
Protein S100-A8

1

5

High-throughput

0.479

High

401457

JUN
Transcription factor Jun

1

13

Small-scale

0.479

High

412030

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.479

High

414179

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.479

High

416355

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

431556

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.479

High

433591

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

449551

HMGB1
High mobility group protein B1

1

15

High-throughput

0.479

High

487150

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

499548

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

523535

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

542194

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

620128

PAX7
Paired box protein Pax-7

1

7

High-throughput

0.479

High

639675

IKBA
NF-kappa-B inhibitor alpha

1

4

Small-scale

0.479

High

649035

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.479

High

649039

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.479

High

649043

1433S
14-3-3 protein sigma

1

3

High-throughput

0.479

High

649049

MYH9
Myosin-9

1

8

High-throughput

0.479

High

649050

MYH10
Myosin-10

1

8

High-throughput

0.479

High

649051

SOX6
Transcription factor SOX-6

1

18

High-throughput

0.479

High

649055

VHL
von Hippel-Lindau disease tumor suppressor

1

8

High-throughput

0.479

High

649062

MATR3
Matrin-3

1

3

High-throughput

0.479

High

649063

RANG
Ran-specific GTPase-activating protein

1

3

High-throughput

0.479

High

649065

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

649066

SOX2
Transcription factor SOX-2

1

18

High-throughput

0.479

High

649068

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

649069

DYN2
Dynamin-2

1

1

High-throughput

0.479

High

649070

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

649075

GSC
Homeobox protein goosecoid

1

5

High-throughput

0.479

High

649077

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.479

High

649078

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.479

High

649080

H4
Histone H4

1

5

High-throughput

0.479

High

649081

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.479

High

649082

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.479

High

649083

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

3

High-throughput

0.479

High

649087

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

High-throughput

0.479

High

649090

TLE3
Transducin-like enhancer protein 3

1

9

High-throughput

0.479

High

649091

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.479

High

649092

KLC1
Kinesin light chain 1

1

2

High-throughput

0.479

High

649094

FOXO1
Forkhead box protein O1

1

12

High-throughput

0.479

High

649096

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.479

High

649099

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

649100

SMAD4
Mothers against decapentaplegic homolog 4

1

6

Small-scale

0.479

High

649101

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

649103

CUL4A
Cullin-4A

1

7

Small-scale

0.479

High

649107

SRC8
Src substrate cortactin

1

3

High-throughput

0.479

High

649110

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

Small-scale

0.479

High

649113

NONO
Non-POU domain-containing octamer-binding protein

1

6

High-throughput

0.479

High

649114

ELOC
Elongin-C

1

2

High-throughput

0.479

High

649121

DDB1
DNA damage-binding protein 1

1

7

Small-scale

0.479

High

649129

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

649130

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.479

High

649135

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

649139

SP7
Transcription factor Sp7

1

7

High-throughput

0.479

High

649140

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

649141

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

649142

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

649143

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

649144

EGLN2
Prolyl hydroxylase EGLN2

1

14

Small-scale

0.479

High

649145

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

649147

FEV
Protein FEV

1

11

High-throughput

0.479

High

649161

NANOG
Homeobox protein NANOG

1

7

Small-scale

0.479

High

649162

RTN4
Reticulon-4

1

1

High-throughput

0.479

High

649167

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

649172

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

649173

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

649176

SGT1
Protein SGT1 homolog

1

8

High-throughput

0.479

High

649180

NEMO
NF-kappa-B essential modulator

1

13

Small-scale

0.479

High

321372

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.460

High

168886

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.458

High

559331

H13
Histone H1.3

1

0

High-throughput

0.458

High

574246

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

574924

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

649034

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

649041

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

649047

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

649053

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

649057

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

649079

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

649085

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

649088

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.458

High

649111

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

649160

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

Small-scale

0.458

High

649174

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

607884

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.457

High

649037

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.457

High

649133

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.439

High

649076

MYL6
Myosin light polypeptide 6

1

3

High-throughput

0.437

High

649108

FLOT2
Flotillin-2

1

1

High-throughput

0.437

High

649125

TENS3
Tensin-3

1

4

High-throughput

0.437

High

649127

MPRIP
Myosin phosphatase Rho-interacting protein

1

10

High-throughput

0.437

High

649136

OR6K3
Olfactory receptor 6K3

1

1

High-throughput

0.437

High

649073

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

0

High-throughput

0.347

High

649154

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

0

High-throughput

0.347

High

649124

DCA15
DDB1- and CUL4-associated factor 15

3

0

Small-scale

0.342

High

515136

ADHX
Alcohol dehydrogenase class-3

1

0

High-throughput

0.282

High

649163

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.282

High

224606

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

454078

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

649036

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.279

Low

649097

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

649128

BOP
Protein Bop

1

0

High-throughput

0.279

Low

555080

CD44
CD44 antigen

1

0

High-throughput

0.261

Low

207689

SYT7
Synaptotagmin-7

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024