HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29881947
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 796
+	Hs
		384184 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		NTRK1_HUMAN (1-796): 0: 621: 100.00
+	Hs
		146632 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72
+	Hs
		433229 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		FGFR1_HUMAN (195-794): 0: 545: 26.34
+	Hs
		412212 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72
+	Hs
		412008 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55
+	Hs
		147391 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98
+	Hs
		412036 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64
+	Hs
		412104 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36
+	Hs
		434125 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		RET_HUMAN (391-794): 3.5e-114: 374: 30.44
+	Mm
		403421 SRC_MOUSE (1-176): 2.21e-43: 153: 15.76		RET_MOUSE (458-794): 1.13e-112: 370: 35.45
+	Hs
		146583 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		146667 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		147378 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		435518 SRC_HUMAN (1-176): 2.1e-43: 153: 15.76		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		147373 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		412153 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49
+	Hs
		433332 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49
+	Mm
		193373 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		INSR_MOUSE (493-777): 3.11e-66: 241: 41.95
+	Mm
		403410 SRC_MOUSE (1-176): 2.21e-43: 153: 15.76		INSR_MOUSE (493-777): 3.11e-66: 241: 41.95
+	Hs
		256861 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		ALK_HUMAN (505-790): 8.72e-63: 231: 42.07