HitPredict

Interactor 1: PTPRT (O14522)
Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)
Gene: PTPRT

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	1.00	0.733

Property	Details
Experiments	28065597
Identification Methods	two hybrid, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009986 - cell surface GO:0016020 - membrane GO:0019903 - protein phosphatase binding and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1441 Hs			1 1210
+	Hs
		338458 PTPRK_HUMAN (23-1440): 0: 1143: 58.16		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		146927 PTPRT_HUMAN (26-1441): 0: 1197: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		146920 PTPRT_HUMAN (26-1441): 0: 1197: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383818 PTPRK_HUMAN (23-1440): 0: 1143: 58.16		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		337909 PTPRA_HUMAN (728-1441): 0: 751: 32.78		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337942 PTPRE_HUMAN (777-1441): 0: 732: 35.21		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383597 PTPRA_HUMAN (728-1441): 0: 751: 32.78		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338349 PTPRJ_HUMAN (342-1440): 5.6e-121: 412: 17.10		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339009 PTPRH_HUMAN (1165-1440): 1.53e-94: 333: 29.64		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383771 PTPRJ_HUMAN (342-1440): 5.6e-121: 412: 17.10		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		411394 PTPRK_HUMAN (23-1440): 0: 1143: 58.16		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		383836 PTPRO_HUMAN (1145-1435): 4.14e-98: 345: 27.27		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		602004 PTPRH_HUMAN (1165-1440): 1.53e-94: 333: 29.64		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		434133 PTPRA_HUMAN (728-1441): 0: 751: 32.78		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		411369 PTPRJ_HUMAN (342-1440): 5.6e-121: 412: 17.10		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		665257 PTPRO_HUMAN (1145-1435): 4.14e-98: 345: 27.27		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		411401 PTPRO_HUMAN (1145-1435): 4.14e-98: 345: 27.27		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		992570 PTPRJ_HUMAN (342-1440): 5.6e-121: 412: 17.10		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		796584 PTPRO_HUMAN (1145-1435): 4.14e-98: 345: 27.27		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Mm
		93651 PTPRO_MOUSE (1150-1435): 1.03e-95: 338: 28.87		FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64