HitPredict

Interactor 1: FCHO1 (O14526)
F-BAR domain only protein 1
Gene: FCHO1

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	28514442, 27237791
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 889 Hs			1 864
+	Hs
		1001598 FCHO2_HUMAN (1-889): 8.07e-177: 533: 43.23		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		147146 FCHO1_HUMAN (1-889): 0: 549: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		787902 FCHO2_HUMAN (1-889): 8.07e-177: 533: 43.23		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		1309722 SGIP1_HUMAN (211-888): 1.22e-83: 288: 27.31		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		147162 FCHO1_HUMAN (1-889): 0: 549: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1001577 FCHO2_HUMAN (1-889): 8.07e-177: 533: 43.23		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		787963 SGIP1_HUMAN (211-888): 1.22e-83: 288: 27.31		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		788006 SGIP1_MOUSE (211-888): 4.38e-81: 280: 27.31		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		1078901 SGIP1_HUMAN (211-888): 1.22e-83: 288: 27.31		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1309721 SGIP1_HUMAN (211-888): 1.22e-83: 288: 27.31		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		1078897 FNBP1_HUMAN (8-453): 8.22e-59: 214: 13.35		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1078931 PACN3_HUMAN (4-335): 1.02e-58: 208: 17.88		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		1145116 PACN2_RAT (5-384): 3.52e-68: 237: 16.55		EHD1_RAT (12-102): 9.73e-24: 108: 29.67
+	Hs
		297971 FCSD2_HUMAN (14-607): 6.45e-50: 190: 10.78		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Sp
		195123 SYP1_SCHPO (2-849): 2.61e-50: 192: 13.22		YHLA_SCHPO (11-348): 2.49e-29: 128: 27.64
+	Sc
		635278 SYP1_YEAST (17-874): 6.36e-51: 195: 13.84		EDE1_YEAST (9-832): 2.37e-28: 125: 10.51
+	Hs
		1315998 PACN1_HUMAN (5-387): 4.8e-67: 232: 17.12		EHD3_HUMAN (198-365): 3.43e-14: 78.1: 26.19
+	Hs
		1331792 PACN2_HUMAN (5-384): 1.7e-63: 223: 15.64		EHD1_HUMAN (198-366): 4.94e-14: 77.8: 25.44
+	At
		1323982 Q9FKM4_ARATH (413-888): 1.87e-52: 196: 15.77		Q9LM78_ARATH (3-400): 1.53e-17: 89.7: 13.22
+	At
		95256 Q9FKM4_ARATH (413-888): 1.87e-52: 196: 15.77		F4HY32_ARATH (2-187): 1.13e-16: 87.4: 17.17