HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31748929
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0050728 - negative regulation of inflammatory response GO:0072540 - T-helper 17 cell lineage commitment GO:0097398 - cellular response to interleukin-17
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 770
+	Mm
		193377 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		146671 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		454804 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		412065 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		442788 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		403422 SRC_MOUSE (35-219): 1.74e-45: 160: 17.13		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		433628 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		522829 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		411624 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776611 BLK_HUMAN (34-219): 1.13e-42: 152: 19.01		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		256851 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		522836 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		146672 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		786656 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		146609 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		849911 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786637 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		193381 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		STAT6_MOUSE (1-761): 0: 668: 25.69
+	Dm
		1096410 Q7JVF1_DROME (26-218): 2.24e-49: 166: 18.04		STAT_DROME (1-755): 0: 648: 22.58
+	Dm
		1096415 Q8INY1_DROME (21-221): 8.48e-46: 163: 22.17		STAT_DROME (1-755): 0: 648: 22.58