Protein: HDAC5
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Histone deacetylase mHDA1)

Gene: HDAC5
Organism: Mus musculus
Interactions: 89
UniProt ID: Q9Z2V6

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1225308

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

Small-scale

0.515

High

655065

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

1224655

MEF2D
Myocyte-specific enhancer factor 2D

1

20

High-throughput

0.457

High

98083

DESP
Desmoplakin

1

20

High-throughput

0.445

High

98235

FRY
Protein furry homolog

1

2

High-throughput

0.445

High

108316

FBX50
F-box only protein 50

1

1

High-throughput

0.445

High

109318

GCP6
Gamma-tubulin complex component 6

1

9

High-throughput

0.445

High

148595

PSB1
Proteasome subunit beta type-1

1

5

High-throughput

0.445

High

204887

BHMT1
Betaine--homocysteine S-methyltransferase 1

1

1

High-throughput

0.445

High

267044

1433S
14-3-3 protein sigma

1

20

High-throughput

0.445

High

369953

CO3
Complement C3

1

6

High-throughput

0.445

High

439054

LDHA
L-lactate dehydrogenase A chain

1

11

High-throughput

0.445

High

459402

ALBU
Albumin

1

4

High-throughput

0.445

High

465829

ENPL
Endoplasmin

1

15

High-throughput

0.445

High

481012

PGK1
Phosphoglycerate kinase 1

1

6

High-throughput

0.445

High

518561

ANXA1
Annexin A1

1

5

High-throughput

0.445

High

536211

CO1A1
Collagen alpha-1(I) chain

1

2

High-throughput

0.445

High

570782

MDHC
Malate dehydrogenase, cytoplasmic

1

11

High-throughput

0.445

High

597667

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.445

High

602943

ENOA
Alpha-enolase

1

9

High-throughput

0.445

High

602950

ENOG
Gamma-enolase

1

9

High-throughput

0.445

High

613661

CATD
Cathepsin D

1

1

High-throughput

0.445

High

638877

ENOB
Beta-enolase

1

9

High-throughput

0.445

High

659351

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

3

High-throughput

0.445

High

664243

CATA
Catalase

1

3

High-throughput

0.445

High

731968

SCP2
Sterol carrier protein 2

1

11

High-throughput

0.445

High

750354

NEDD1
Protein NEDD1

1

20

High-throughput

0.445

High

771539

TSP1
Thrombospondin-1

1

6

High-throughput

0.445

High

912315

KPYM
Pyruvate kinase PKM

1

6

High-throughput

0.445

High

926063

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.445

High

945986

EF2
Elongation factor 2

1

7

High-throughput

0.445

High

946727

GCP3
Gamma-tubulin complex component 3

1

9

High-throughput

0.445

High

972328

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.445

High

981774

RAN
GTP-binding nuclear protein Ran

1

7

High-throughput

0.445

High

986968

PROF1
Profilin-1

1

2

High-throughput

0.445

High

994033

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

16

High-throughput

0.445

High

996638

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

999294

1433F
14-3-3 protein eta

1

20

High-throughput

0.445

High

1014066

TBG1
Tubulin gamma-1 chain

1

20

High-throughput

0.445

High

1021087

PEDF
Pigment epithelium-derived factor

1

4

High-throughput

0.445

High

1021203

PKP1
Plakophilin-1

1

20

High-throughput

0.445

High

1190113

MTUS2
Microtubule-associated tumor suppressor candidate 2 homolog

1

20

High-throughput

0.445

High

1190515

FBW1A
F-box/WD repeat-containing protein 1A

1

15

High-throughput

0.445

High

1210441

FBW1B
F-box/WD repeat-containing protein 11

1

20

High-throughput

0.445

High

1222697

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.445

High

1224102

SPT6H
Transcription elongation factor SPT6

1

9

High-throughput

0.445

High

1229313

GIT1
ARF GTPase-activating protein GIT1

1

8

High-throughput

0.445

High

1260687

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

14

High-throughput

0.445

High

1274614

DSG1B
Desmoglein-1-beta

1

5

High-throughput

0.445

High

1296910

GCP5
Gamma-tubulin complex component 5

1

9

High-throughput

0.445

High

1297417

MZT1
Mitotic-spindle organizing protein 1

1

1

High-throughput

0.445

High

1341605

ARHGC
Rho guanine nucleotide exchange factor 12

1

9

High-throughput

0.445

High

1362223

MIC25
MICOS complex subunit Mic25

1

2

High-throughput

0.445

High

1362874

GCP2
Gamma-tubulin complex component 2

1

9

High-throughput

0.445

High

1365305

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

7

High-throughput

0.445

High

1408735

HOME3
Homer protein homolog 3

1

13

High-throughput

0.445

High

1423632

MZT2
Mitotic-spindle organizing protein 2

1

1

High-throughput

0.445

High

1423733

ACO13
Acyl-coenzyme A thioesterase 13

1

1

High-throughput

0.445

High

1424429

ARHG7
Rho guanine nucleotide exchange factor 7

1

11

High-throughput

0.445

High

1440898

FMNL1
Formin-like protein 1

1

7

High-throughput

0.445

High

1455877

NDK7
Nucleoside diphosphate kinase homolog 7

1

4

High-throughput

0.445

High

1455937

PCM1
Pericentriolar material 1 protein

1

3

High-throughput

0.445

High

1490139

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.445

High

1490173

NFAT5
Nuclear factor of activated T-cells 5

1

20

High-throughput

0.445

High

313019

FA5
Coagulation factor V

1

4

High-throughput

0.407

High

380675

HBA
Hemoglobin subunit alpha

1

4

High-throughput

0.407

High

405577

CFAB
Complement factor B

1

5

High-throughput

0.407

High

469650

MDHM
Malate dehydrogenase, mitochondrial

1

9

High-throughput

0.407

High

522320

NID1
Nidogen-1

1

1

High-throughput

0.407

High

540230

FINC
Fibronectin

1

3

High-throughput

0.407

High

619190

THRB
Prothrombin

1

4

High-throughput

0.407

High

635488

PLMN
Plasminogen

1

5

High-throughput

0.407

High

704323

MUG1
Murinoglobulin-1

1

6

High-throughput

0.407

High

906480

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.407

High

1180539

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

4

High-throughput

0.407

High

1190092

CC177
Coiled-coil domain-containing protein 177

1

17

High-throughput

0.407

High

1223136

GDIB
Rab GDP dissociation inhibitor beta

1

1

High-throughput

0.407

High

1223279

ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3

1

2

High-throughput

0.407

High

1233001

A2MG
Alpha-2-macroglobulin-P

1

6

High-throughput

0.407

High

1240608

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

7

High-throughput

0.407

High

1297670

RHG12
Rho GTPase-activating protein 12

1

9

High-throughput

0.407

High

1298218

MIC60
MICOS complex subunit Mic60

1

19

High-throughput

0.407

High

1353889

TBG2
Tubulin gamma-2 chain

1

20

High-throughput

0.407

High

1362876

THIKA
3-ketoacyl-CoA thiolase A, peroxisomal

1

4

High-throughput

0.407

High

1362879

TRFE
Serotransferrin

1

1

High-throughput

0.407

High

1424073

GCP4
Gamma-tubulin complex component 4

1

9

High-throughput

0.407

High

1455934

AMFR
E3 ubiquitin-protein ligase AMFR

1

10

High-throughput

0.407

High

1490167

ECI2
Enoyl-CoA delta isomerase 2

1

5

High-throughput

0.407

High

1490179

TAGL2
Transgelin-2

1

12

High-throughput

0.407

High


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Last updated: 11Aug2025