HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	15385932
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1124
+	Mm
		193387 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		JAK2_MOUSE (4-1101): 0: 897: 48.38
+	Mm
		980968 YES_MOUSE (30-223): 1.41e-50: 173: 15.11		JAK2_MOUSE (4-1101): 0: 897: 48.38
+	Hs
		238424 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		147366 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (784-1105): 3.14e-89: 298: 29.63
+	Mm
		69807 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		B1ASP2_MOUSE (764-1119): 4.65e-38: 157: 18.25
+	Hs
		147392 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		338763 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		147370 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		337789 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (525-790): 4.96e-16: 85.5: 29.14
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00