HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 4684
+	Hs
		147511 SOCS6_HUMAN (1-535): 0: 701: 100.00		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		521454 SRC_HUMAN (257-495): 1.3e-50: 183: 15.48		ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94
+	Hs
		164551 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		SPTN2_HUMAN (1390-3166): 2.85e-25: 118: 12.24
+	Hs
		164555 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		SPTN2_HUMAN (1390-3166): 2.85e-25: 118: 12.24
+	Hs
		411676 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		411724 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		GOGB1_HUMAN (2666-3718): 4.33e-13: 78.9: 11.65
+	Hs
		433700 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		411682 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		411889 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92
+	Hs
		411581 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Hs
		411983 FYN_HUMAN (324-506): 2.87e-51: 185: 15.63		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Hs
		181844 SOCS1_HUMAN (379-535): 5.8e-42: 151: 26.75		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		433710 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		434078 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92
+	Hs
		433558 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Hs
		551599 NCK1_HUMAN (206-466): 1.38e-44: 163: 15.44		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Hs
		129277 P85B_HUMAN (380-491): 1.89e-14: 78.2: 27.68		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53