HitPredict

Interactor 1: DC1I1 (O14576)
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)
Gene: DYNC1I1

Interactor 2: DYLT3 (P51808)
Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like)
Gene: DYNLT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	28718761, 12475239, 33961781
Identification Methods	proximity labelling technology, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Dynein_IC2~Tctex-1
Common GO terms	GO:0000776 - kinetochore GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005868 - cytoplasmic dynein complex
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 116
+	Hs
		148060 DC1I1_HUMAN (1-645): 7.32e-150: 450: 100.00		DYLT1_HUMAN (1-114): 9.84e-46: 145: 53.51
+	Hs
		850528 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DYLT3_HUMAN (1-116): 4.5e-47: 148: 100.00
+	Hs
		928590 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DYLT1_HUMAN (1-114): 9.84e-46: 145: 53.51
+	Dm
		1096837 DYIN_DROME (6-635): 2.04e-103: 330: 46.46		DYLT_DROME (5-114): 3.35e-42: 136: 46.36
+	Hs
		928646 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DYLT1_HUMAN (1-114): 9.84e-46: 145: 53.51
+	Hs
		928656 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DYLT1_HUMAN (1-114): 9.84e-46: 145: 53.51
+	Cr
		65480 A8IJZ3_CHLRE (157-608): 1.49e-86: 283: 22.20		O04355_CHLRE (8-112): 1.25e-35: 120: 20.76
+	Hs
		1261757 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DYT2B_HUMAN (2-111): 1.38e-36: 123: 21.24
+	Hs
		1262253 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DYT2B_HUMAN (2-111): 1.38e-36: 123: 21.24
+	Hs
		1127235 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DYLT4_HUMAN (32-112): 1.45e-25: 97: 20.73
+	Hs
		1127237 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DYLT4_HUMAN (32-112): 1.45e-25: 97: 20.73
+	Hs
		792944 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DYLT3_HUMAN (1-116): 4.5e-47: 148: 100.00
+	Hs
		792965 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DYLT1_HUMAN (1-114): 9.84e-46: 145: 53.51
+	Hs
		793018 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DYT2B_HUMAN (2-111): 1.38e-36: 123: 21.24