HitPredict

Interactor 1: UTY (O14607)
Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY)
Gene: UTY

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.618

Property	Details
Experiments	19047629, 19433796
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0007507 - heart development GO:0044666 - MLL3/4 complex
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1347 Hs			1 2063
+	Hs
		183115 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		150104 UTY_HUMAN (1-1340): 0: 1481: 100.00		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Mm
		251035 KDM6A_MOUSE (1-1347): 0: 1418: 81.93		SMCA4_MOUSE (351-700): 1.27e-23: 112: 16.81
+	Hs
		183137 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Mm
		1111922 KDM6B_MOUSE (508-1345): 0: 863: 42.69		SMCA4_MOUSE (351-700): 1.27e-23: 112: 16.81
+	Hs
		1057016 CDC23_HUMAN (14-491): 3.12e-59: 217: 16.27		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		174891 OGT1_HUMAN (165-614): 1.63e-32: 139: 10.07		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		175053 OGT1_HUMAN (165-614): 1.63e-32: 139: 10.07		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		311815 CTR9_HUMAN (201-574): 1.09e-14: 81.6: 11.11		TACC2_HUMAN (134-1918): 4.74e-16: 87.2: 8.66
+	Hs
		1056898 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		92366 CTR9_HUMAN (201-574): 1.09e-14: 81.6: 11.11		E9PBC6_HUMAN (144-1942): 4.3e-13: 77.5: 7.62
+	Hs
		1056827 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		867121 DNJC7_HUMAN (220-395): 1.7e-17: 89.3: 11.70		SC24C_HUMAN (219-600): 6.59e-10: 66.7: 20.49