HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1257 Hs			1 248
+	Hs
		151760 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		151765 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		151714 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		151720 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		151758 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		151776 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Dm
		955052 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		1433E_DROME (2-247): 2.8e-144: 405: 58.07
+	Dm
		664678 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Hs
		684422 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		683873 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		910201 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		724526 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927703 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647417 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		646680 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683852 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		905303 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		683169 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		982659 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		724525 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16