HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	28330616, 25036637
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 499
+	Hs
		151881 IRS4_HUMAN (1-1257): 0: 1632: 100.00		Q9BPW0_HUMAN (3-483): 0: 544: 99.38
+	Hs
		151650 IRS4_HUMAN (1-1257): 0: 1632: 100.00		PPE1_HUMAN (156-487): 8.16e-68: 231: 34.12
+	Hs
		906216 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79