Protein: RRP4
Exosome complex component RRP4 (Ribosomal RNA-processing protein 4)

Gene: RRP4
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P38792

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 - nuclear-transcribed mRNA catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

804722

RRP41
Exosome complex component SKI6

9

20

Small-scale

0.971

High

804730

RRP46
Exosome complex component RRP46

9

20

Small-scale

0.970

High

804734

CSL4
Exosome complex component CSL4

9

6

Small-scale

0.970

High

804749

RRP45
Exosome complex component RRP45

7

20

Small-scale

0.962

High

672883

RRP43
Exosome complex component RRP43

6

0

Small-scale

0.895

High

804760

RRP40
Exosome complex component RRP40

3

8

High-throughput

0.855

High

804733

MPP6
M-phase phosphoprotein 6 homolog

4

0

Small-scale

0.853

High

804726

MTR3
Exosome complex component MTR3

4

0

Small-scale

0.848

High

804744

DHR1
Probable ATP-dependent RNA helicase DHR1

3

3

High-throughput

0.827

High

804759

RRP44
Exosome complex exonuclease DIS3

14

13

Small-scale

0.761

High

804766

RRP6
Exosome complex exonuclease RRP6

14

9

Small-scale

0.760

High

804723

MTR4
ATP-dependent RNA helicase DOB1

2

11

Small-scale

0.754

High

804761

SKI7
Superkiller protein 7

7

3

Small-scale

0.745

High

804747

RRP5
rRNA biogenesis protein RRP5

2

1

High-throughput

0.737

High

804769

RRP42
Exosome complex component RRP42

5

20

Small-scale

0.714

High

804711

LRP1
Exosome complex protein LRP1

6

0

Small-scale

0.702

High

798208

ENP1
Essential nuclear protein 1

3

1

High-throughput

0.640

High

804732

NRD1
Protein NRD1

3

0

Small-scale

0.628

High

763827

SKI2
Antiviral helicase SKI2

1

11

High-throughput

0.618

High

609055

SKI3
Superkiller protein 3

2

0

High-throughput

0.588

High

677385

KRR1
KRR1 small subunit processome component

2

1

High-throughput

0.584

High

804721

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

804746

UTP14
U3 small nucleolar RNA-associated protein 14

2

1

High-throughput

0.584

High

804755

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

804741

IMA1
Importin subunit alpha

2

0

High-throughput

0.576

High

523863

HSP71
Heat shock protein SSA1

2

2

Small-scale

0.571

High

526629

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

804716

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

804712

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.547

High

804740

SKI8
Antiviral protein SKI8

1

8

High-throughput

0.541

High

522348

MPPB
Mitochondrial-processing peptidase subunit beta

2

2

High-throughput

0.537

High

544784

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

804146

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.536

High

410117

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

433627

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

435075

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

435949

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

436403

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

673172

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

674609

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

678388

PWP2
Periodic tryptophan protein 2

1

7

High-throughput

0.479

High

689441

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

754274

DCA13
Protein SOF1

1

11

High-throughput

0.479

High

763567

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

776566

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

804714

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

Small-scale

0.479

High

804715

UTP7
U3 small nucleolar RNA-associated protein 7

1

9

High-throughput

0.479

High

804717

UTP18
U3 small nucleolar RNA-associated protein 18

1

1

High-throughput

0.479

High

804724

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

High-throughput

0.479

High

804725

NOL10
Ribosome biogenesis protein ENP2

1

1

High-throughput

0.479

High

804729

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

804735

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

804737

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

804738

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

804742

UTP17
NET1-associated nuclear protein 1

1

7

High-throughput

0.479

High

804743

UTP5
U3 small nucleolar RNA-associated protein 5

1

9

High-throughput

0.479

High

804745

UTP15
U3 small nucleolar RNA-associated protein 15

1

10

High-throughput

0.479

High

804750

UTP13
U3 small nucleolar RNA-associated protein 13

1

12

High-throughput

0.479

High

804751

UTP21
U3 small nucleolar RNA-associated protein 21

1

8

High-throughput

0.479

High

804752

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

1

High-throughput

0.479

High

804754

RRP9
Ribosomal RNA-processing protein 9

1

11

High-throughput

0.479

High

804756

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

804757

UTP4
U3 small nucleolar RNA-associated protein 4

1

6

High-throughput

0.479

High

804758

RCL1
rRNA processing protein RCL1

1

1

High-throughput

0.479

High

804763

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

804764

FCF2
rRNA-processing protein FCF2

1

1

High-throughput

0.479

High

804768

UTP12
U3 small nucleolar RNA-associated protein 12

1

8

High-throughput

0.479

High

804770

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

804771

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

804773

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

149749

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

512427

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

594356

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

670679

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

707024

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734966

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

758368

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

778317

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

804718

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

804719

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

804720

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

804731

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

804736

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

804739

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

804748

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

804762

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

804765

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

804767

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

804772

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

741527

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

512996

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

753357

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

802156

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

392693

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

804728

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

804753

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.426

High

778981

MYO3
Myosin-3

1

0

High-throughput

0.269

Low

376301

YPT1
GTP-binding protein YPT1

1

0

Small-scale

0.249

Low

804727

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

453584

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

482011

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.232

Low

804713

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025