HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: DPY30 (Q9C005)
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
Gene: DPY30

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	24981860, 17178841
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0044666 - MLL3/4 complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 5537 Hs			1 99
+	Dm
		1129081 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		DPY30_DROME (42-99): 1.39e-24: 91.7: 51.72
+	Sp
		252202 SET1_SCHPO (5320-5537): 5.36e-66: 247: 34.30		SDC1_SCHPO (48-89): 9.88e-13: 60.5: 47.62
+	Hs
		975318 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1318622 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		165713 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1318624 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00
+	Hs
		1243840 KMT2C_HUMAN (223-338): 3.09e-09: 66.3: 40.34		DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00