HitPredict

Interactor 1: APAF (O14727)
Apoptotic protease-activating factor 1 (APAF-1)
Gene: APAF1

Interactor 2: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 0.60 0.563

The method score is based on:

Property Details
Experiments 12874265, 11550094
Identification Methods anti tag coimmunoprecipitation, experimental interaction detection
Interaction Type physical association, cleavage reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0051402 - neuron apoptotic process
and 1 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 1248
Hs

1 277
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024