HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.891

The method score is based on:

Property Details
Experiments 26045165, 9430655, 15161943, 15467741
Identification Methods pull down, two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EBP50_C~FERM_C
Common GO terms GO:0005737 - cytoplasm
GO:0008285 - negative regulation of cell population proliferation
GO:0008360 - regulation of cell shape
GO:0016020 - membrane
GO:0030036 - actin cytoskeleton organization
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 358
Hs

1 595
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024