Protein: TANK
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)

Gene: TANK
Organism: Homo sapiens
Interactions: 240
UniProt ID: Q92844

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0007165 - signal transduction
GO:0007249 - canonical NF-kappaB signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1271780

TBK1
Serine/threonine-protein kinase TBK1

26

5

Small-scale

0.767

High

1020843

TRAF2
TNF receptor-associated factor 2

13

9

Small-scale

0.762

High

1024723

TRAF3
TNF receptor-associated factor 3

12

10

Small-scale

0.760

High

1271790

NEMO
NF-kappa-B essential modulator

10

1

Small-scale

0.757

High

1050245

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

8

5

Small-scale

0.754

High

1023743

TRAF1
TNF receptor-associated factor 1

6

8

Small-scale

0.733

High

1271730

TANK
TRAF family member-associated NF-kappa-B activator

5

1

Small-scale

0.708

High

1036307

BIRC2
Baculoviral IAP repeat-containing protein 2

4

2

Small-scale

0.704

High

129583

TRAF5
TNF receptor-associated factor 5

3

9

Small-scale

0.664

High

861870

PLK1
Serine/threonine-protein kinase PLK1

3

0

Small-scale

0.659

High

1056441

IRF3
Interferon regulatory factor 3

3

2

Small-scale

0.640

High

278700

BODG
Gamma-butyrobetaine dioxygenase

3

0

High-throughput

0.638

High

1245111

TNIP2
TNFAIP3-interacting protein 2

3

0

High-throughput

0.638

High

1271787

TRAF6
TNF receptor-associated factor 6

2

10

Small-scale

0.624

High

167592

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

5

Small-scale

0.621

High

1125303

ZC12A
Endoribonuclease ZC3H12A

2

0

Small-scale

0.613

High

158518

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

5

Small-scale

0.611

High

255967

OBSL1
Obscurin-like protein 1

2

1

High-throughput

0.611

High

1026638

FADD
FAS-associated death domain protein

2

4

Small-scale

0.611

High

1216095

TCAM1
TIR domain-containing adapter molecule 1

2

1

Small-scale

0.611

High

1271744

CEP63
Centrosomal protein of 63 kDa

2

0

High-throughput

0.604

High

791826

HD
Huntingtin

2

1

High-throughput

0.596

High

331398

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

1

High-throughput

0.586

High

639622

TNR5
Tumor necrosis factor receptor superfamily member 5

2

1

Small-scale

0.563

High

1267509

TSC1
Hamartin

1

0

High-throughput

0.558

High

1271731

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.552

High

1043719

ASPP2
Apoptosis-stimulating of p53 protein 2

1

0

High-throughput

0.549

High

171158

CETN3
Centrin-3

1

1

High-throughput

0.536

High

272657

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.536

High

296416

STK10
Serine/threonine-protein kinase 10

1

1

High-throughput

0.536

High

580081

K1C15
Keratin, type I cytoskeletal 15

1

2

High-throughput

0.536

High

599700

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

High-throughput

0.536

High

645946

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

1

High-throughput

0.536

High

738793

SPB5
Serpin B5

1

1

High-throughput

0.536

High

770656

TXLNA
Alpha-taxilin

1

2

High-throughput

0.536

High

820353

SPB4
Serpin B4

1

1

High-throughput

0.536

High

821882

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.536

High

822116

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.536

High

822337

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

835477

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

835916

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

845649

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.536

High

871711

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

902700

SUMO2
Small ubiquitin-related modifier 2

1

1

Small-scale

0.536

High

1035945

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

Small-scale

0.536

High

1064003

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.536

High

1066484

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.536

High

1101517

KIF7
Kinesin-like protein KIF7

1

1

High-throughput

0.536

High

1119013

AMOT
Angiomotin

1

1

High-throughput

0.536

High

1151623

OTU7B
OTU domain-containing protein 7B

1

1

High-throughput

0.536

High

1154019

K2C80
Keratin, type II cytoskeletal 80

1

1

High-throughput

0.536

High

1167943

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.536

High

1222254

AMOL1
Angiomotin-like protein 1

1

2

High-throughput

0.536

High

1257122

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

High-throughput

0.536

High

1271736

TBC31
TBC1 domain family member 31

1

1

High-throughput

0.536

High

1271747

KIF2C
Kinesin-like protein KIF2C

1

2

High-throughput

0.536

High

1271748

CDC6
Cell division control protein 6 homolog

1

1

High-throughput

0.536

High

1271752

TRAF4
TNF receptor-associated factor 4

1

10

High-throughput

0.536

High

1271758

SDCB2
Syntenin-2

1

1

High-throughput

0.536

High

1271759

RNF41
E3 ubiquitin-protein ligase NRDP1

1

5

High-throughput

0.536

High

1271767

TXLNG
Gamma-taxilin

1

3

High-throughput

0.536

High

1271785

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.536

High

950238

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.518

High

1271751

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.518

High

1271782

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.518

High

61434

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

182189

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.513

High

214730

SSNA1
Microtubule nucleation factor SSNA1

1

0

High-throughput

0.513

High

257392

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.513

High

320557

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.513

High

321609

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.513

High

428611

INVO
Involucrin

1

0

High-throughput

0.513

High

451793

ANXA4
Annexin A4

1

0

High-throughput

0.513

High

586897

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

608880

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

674337

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.513

High

678380

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

682918

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.513

High

719570

MERL
Merlin

1

0

High-throughput

0.513

High

740224

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.513

High

777658

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

793021

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

0

High-throughput

0.513

High

842380

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.513

High

851344

NEK2
Serine/threonine-protein kinase Nek2

1

0

High-throughput

0.513

High

872559

EPHB4
Ephrin type-B receptor 4

1

0

High-throughput

0.513

High

885588

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

906777

NCS1
Neuronal calcium sensor 1

1

0

High-throughput

0.513

High

929957

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

942015

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.513

High

999637

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

1038907

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

0

High-throughput

0.513

High

1058700

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

1063165

SEPT2
Septin-2

1

0

High-throughput

0.513

High

1065977

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1068621

PLEC
Plectin

1

0

High-throughput

0.513

High

1072269

ELOC
Elongin-C

1

0

High-throughput

0.513

High

1076493

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.513

High

1082018

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

1138845

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.513

High

1140442

K2C79
Keratin, type II cytoskeletal 79

1

0

High-throughput

0.513

High

1145867

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.513

High

1160502

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.513

High

1161516

ULK3
Serine/threonine-protein kinase ULK3

1

0

High-throughput

0.513

High

1161815

FBX38
F-box only protein 38

1

0

High-throughput

0.513

High

1164965

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

High-throughput

0.513

High

1184458

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1191852

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

High-throughput

0.513

High

1199279

SAPC2
Suppressor APC domain-containing protein 2

1

0

High-throughput

0.513

High

1199661

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.513

High

1201432

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.513

High

1205871

GPSM1
G-protein-signaling modulator 1

1

0

High-throughput

0.513

High

1206012

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.513

High

1217687

CCD50
Coiled-coil domain-containing protein 50

1

0

High-throughput

0.513

High

1243149

CC112
Coiled-coil domain-containing protein 112

1

0

High-throughput

0.513

High

1261191

ZFN2B
AN1-type zinc finger protein 2B

1

0

High-throughput

0.513

High

1262650

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

1267834

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.513

High

1271737

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

High-throughput

0.513

High

1271739

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.513

High

1271741

FUBP3
Far upstream element-binding protein 3

1

0

High-throughput

0.513

High

1271745

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1271756

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.513

High

1271762

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.513

High

1271763

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.513

High

1271764

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1271765

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

1271766

PICK1
PRKCA-binding protein

1

0

High-throughput

0.513

High

1271768

PARVA
Alpha-parvin

1

0

High-throughput

0.513

High

1271769

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

1271770

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1271772

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

0

High-throughput

0.513

High

1271775

TEN3
Teneurin-3

1

0

High-throughput

0.513

High

1271778

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

1271779

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.513

High

1271781

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.513

High

1271784

APC7
Anaphase-promoting complex subunit 7

1

0

High-throughput

0.513

High

1271788

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

1271789

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

612895

FBLN1
Fibulin-1

1

1

High-throughput

0.494

High

415432

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.489

High

637009

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

722019

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.489

High

778021

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.489

High

1055029

HABP2
Hyaluronan-binding protein 2

1

1

High-throughput

0.489

High

1058617

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

High-throughput

0.489

High

1220108

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

1

High-throughput

0.489

High

1263130

OIT3
Oncoprotein-induced transcript 3 protein

1

2

High-throughput

0.489

High

1271387

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

2

High-throughput

0.489

High

1271755

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.489

High

395372

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

380659

K2C1
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.479

High

445096

K1C16
Keratin, type I cytoskeletal 16

1

2

High-throughput

0.479

High

502394

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

504507

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

714038

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.479

High

724115

K1C9
Keratin, type I cytoskeletal 9

1

3

High-throughput

0.479

High

751742

GRP75
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

783082

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

1038294

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

Small-scale

0.479

High

1059334

CASP8
Caspase-8

1

1

Small-scale

0.479

High

1146692

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1190041

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.479

High

1254207

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1269280

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1271732

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

3

Small-scale

0.479

High

1271738

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

1271746

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

Small-scale

0.479

High

1271776

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

1271786

Q9UQC1
Heat shock protein 72

1

3

High-throughput

0.479

High

853404

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

863284

COPB
Coatomer subunit beta

1

0

High-throughput

0.460

High

1026336

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.460

High

1271757

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.460

High

127333

IPO5
Importin-5

1

0

High-throughput

0.458

High

152746

ITBP1
Integrin beta-1-binding protein 1

1

0

Small-scale

0.458

High

301951

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

High-throughput

0.458

High

319951

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

867746

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

876864

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

960909

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

962259

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

1027619

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

Small-scale

0.458

High

1042200

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1058264

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

1065555

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

1075524

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

1188655

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1271733

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

Small-scale

0.458

High

1271742

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.458

High

1271774

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

Small-scale

0.458

High

1271754

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.457

High

488003

RARA
Retinoic acid receptor alpha

1

1

Small-scale

0.445

High

928159

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.445

High

584445

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.437

High

62119

PSAL
Puromycin-sensitive aminopeptidase-like protein

1

0

High-throughput

0.426

High

679474

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.426

High

816366

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.426

High

1044562

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.426

High

1079950

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.426

High

353546

IGKC
Immunoglobulin kappa constant

1

2

High-throughput

0.407

High

353709

IGHG1
Immunoglobulin heavy constant gamma 1

1

2

High-throughput

0.407

High

354109

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

352673

TNFA
Tumor necrosis factor

2

0

Small-scale

0.305

High

984106

SRS11
Serine/arginine-rich splicing factor 11

1

0

High-throughput

0.299

High

1271771

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.292

High

488327

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.282

High

680377

SDC4
Syndecan-4

1

0

High-throughput

0.282

High

1031770

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.282

High

118388

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

229880

KIF5C
Kinesin heavy chain isoform 5C

1

0

High-throughput

0.279

Low

353140

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

595700

MIME
Mimecan

1

0

High-throughput

0.279

Low

648568

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

714769

TRY3
Trypsin-3

1

0

High-throughput

0.279

Low

830143

PRI1
DNA primase small subunit

1

0

High-throughput

0.279

Low

1020385

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.279

Low

1123258

SDK2
Protein sidekick-2

1

0

High-throughput

0.279

Low

1130991

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.279

Low

1165070

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.279

Low

1174617

H32
Histone H3.2

1

0

High-throughput

0.279

Low

1204399

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

1220950

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.279

Low

1241726

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

0

High-throughput

0.279

Low

1260111

ARB2A
Cotranscriptional regulator ARB2A

1

0

High-throughput

0.279

Low

1271734

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.279

Low

1271735

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

1271740

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.279

Low

1271743

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.279

Low

1271749

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.279

Low

1271750

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

1271753

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.279

Low

1271760

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

1271761

NOL6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

1271773

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.279

Low

1271777

MRC2
C-type mannose receptor 2

1

0

High-throughput

0.279

Low

1271783

TRM6
tRNA

1

0

High-throughput

0.279

Low

502861

LAMC1
Laminin subunit gamma-1

1

0

High-throughput

0.251

Low

853013

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.249

Low

1172699

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024