HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.749

The method score is based on:

Property Details
Experiments 21804599, 26531778, 16456542, 30631154, 21990315, 23118026, 24012959
Identification Methods pull down, affinity chromatography technology, two hybrid, filter binding
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0008285 - negative regulation of cell population proliferation
GO:0016324 - apical plasma membrane
GO:0030165 - PDZ domain binding
GO:0051898 - negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 358
Hs

1 403
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024