HitPredict

Interactor 1: CHK1 (O14757)
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
Gene: CHEK1

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 20639859
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 476 Hs			1 246
+	Hs
		154163 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	At
		965360 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14332_ARATH (1-241): 4.75e-145: 407: 63.27
+	At
		1280891 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14337_ARATH (1-239): 1.25e-144: 406: 61.73
+	At
		788672 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14333_ARATH (3-241): 4.44e-143: 402: 62.96
+	Hs
		154135 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		154160 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		154171 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		154140 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62