HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	15659383
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	Death~Death, TNFR_c6~TNFR_c6
Common GO terms	GO:0005886 - plasma membrane GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0009986 - cell surface GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0071260 - cellular response to mechanical stimulus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 455
+	Hs
		584310 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00
+	Hs
		154424 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		EDAR_HUMAN (27-450): 4e-77: 249: 14.32
+	Hs
		121420 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57
+	Hs
		154317 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85
+	Hs
		154311 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Hs
		154399 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR19L_HUMAN (61-342): 3.05e-34: 134: 15.64
+	Hs
		154277 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR10C_HUMAN (29-171): 1.03e-19: 90.4: 24.83
+	Hs
		121520 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		TR19L_HUMAN (61-342): 3.05e-34: 134: 15.64
+	Hs
		1274098 TNR25_HUMAN (58-424): 4.73e-60: 203: 19.24		TNR25_HUMAN (39-442): 1.12e-77: 249: 27.36
+	Hs
		584316 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Hs
		584311 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86
+	Hs
		267337 TNR16_HUMAN (53-393): 6.19e-51: 179: 16.30		TNR21_HUMAN (38-339): 1.78e-52: 188: 16.23
+	Hs
		267332 TNR21_HUMAN (52-336): 1.13e-43: 164: 14.63		TNR21_HUMAN (38-339): 1.78e-52: 188: 16.23
+	Hs
		639548 TNR5_HUMAN (44-297): 3.52e-40: 146: 16.79		TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64
+	Hs
		591261 TNR1B_HUMAN (42-277): 3.14e-36: 140: 17.67		TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86
+	Hs
		436603 TNR16_HUMAN (53-393): 6.19e-51: 179: 16.30		TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46
+	Rn
		421806 TNR16_RAT (53-393): 2.11e-50: 177: 16.30		TNR16_RAT (40-301): 5.81e-28: 117: 18.58