HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: NIN (Q8N4C6)
Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)
Gene: NIN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28718761, 34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005813 - centrosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 2090
+	Hs
		1127269 TGO1_HUMAN (195-642): 2.07e-29: 127: 15.45		NIN_HUMAN (1-2090): 0: 617: 100.00
+	Hs
		155102 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		CP250_HUMAN (584-2088): 1.96e-51: 203: 11.45
+	Hs
		154949 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		CENPE_HUMAN (1236-2090): 8.51e-24: 112: 11.72
+	Hs
		154889 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		CE290_HUMAN (1326-2090): 1.25e-17: 92.4: 9.75
+	Hs
		724994 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CP250_HUMAN (584-2088): 1.96e-51: 203: 11.45
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (12-1201): 4.09e-38: 159: 12.98
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (12-1201): 4.09e-38: 159: 12.98
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (37-778): 5.44e-23: 110: 11.55
+	Mm
		93578 DESP_MOUSE (190-642): 1.18e-15: 83.5: 15.27		PLEC_MOUSE (238-1569): 3.8e-36: 153: 14.48
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (37-778): 5.44e-23: 110: 11.55
+	Rn
		222476 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKB_RAT (368-863): 4.55e-15: 84: 18.74
+	Rn
		1186812 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKB_RAT (368-863): 4.55e-15: 84: 18.74
+	Hs
		724839 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PLEC_HUMAN (320-1163): 1.13e-15: 86.3: 13.21
+	Mm
		93570 MYH9_MOUSE (183-642): 2.55e-18: 91.8: 11.55		DESP_MOUSE (1003-2071): 1e-14: 82.8: 11.96
+	Hs
		1137917 MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42		MRCKB_HUMAN (368-855): 2.53e-13: 78.3: 18.87
+	Hs
		1268126 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MY18A_HUMAN (1488-2028): 1.65e-10: 69: 18.93
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (1456-1810): 2.92e-09: 64.8: 24.19
+	Hs
		724943 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MY18A_HUMAN (1488-2028): 1.65e-10: 69: 18.93