Protein: DIG1
Down-regulator of invasive growth 1 (Regulator of STE12 protein 1) (Regulator of sterile twelve 1)

Gene: DIG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 121
UniProt ID: Q03063

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0010570 - regulation of filamentous growth
GO:0045894 - negative regulation of mating-type specific transcription, DNA-templated

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539402

KSS1
Mitogen-activated protein kinase KSS1

8

2

Small-scale

0.755

High

562749

FUS3
Mitogen-activated protein kinase FUS3

6

1

Small-scale

0.742

High

530023

STE12
Protein STE12

12

0

Small-scale

0.728

High

974422

DIG2
Down-regulator of invasive growth 2

6

0

Small-scale

0.697

High

492223

HSP71
Heat shock protein SSA1

4

1

High-throughput

0.666

High

576204

TEC1
Ty transcription activator TEC1

3

0

Small-scale

0.645

High

366780

HSP82
ATP-dependent molecular chaperone HSP82

3

1

High-throughput

0.640

High

972884

IMA1
Importin subunit alpha

2

0

High-throughput

0.565

High

861282

PBP1
PAB1-binding protein 1

2

0

Small-scale

0.561

High

494790

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

512468

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

730540

KDX1
Serine/threonine-protein kinase KDX1

1

2

High-throughput

0.536

High

733230

SA190
SIT4-associating protein SAP190

1

1

High-throughput

0.536

High

777319

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.536

High

961907

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.536

High

389736

CDC25
Cell division control protein 25

1

0

High-throughput

0.518

High

649996

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

425377

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

594358

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.513

High

676317

XPO1
Exportin-1

1

0

High-throughput

0.513

High

974421

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.513

High

974438

SUS1
Transcription and mRNA export factor SUS1

1

0

High-throughput

0.513

High

565749

PHO85
Cyclin-dependent protein kinase PHO85

1

1

High-throughput

0.508

High

593368

CG11
G1/S-specific cyclin CLN1

1

1

Small-scale

0.508

High

593407

CG12
G1/S-specific cyclin CLN2

1

1

Small-scale

0.508

High

743181

BOB1
Protein BOB1

1

1

High-throughput

0.494

High

765858

BOI2
Protein BOI2

1

1

High-throughput

0.494

High

483008

MTAL1
Mating-type protein ALPHA1

1

0

High-throughput

0.486

High

589311

FKBP
FK506-binding protein 1

1

0

High-throughput

0.486

High

755855

LSM12
Protein LSM12

1

0

High-throughput

0.486

High

778445

GTS1
Protein GTS1

1

0

High-throughput

0.486

High

974420

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.486

High

974426

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.486

High

974428

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.486

High

974429

DIB1
Spliceosomal protein DIB1

1

0

High-throughput

0.486

High

746535

IMB2
Importin subunit beta-2

1

0

Small-scale

0.480

High

339808

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

665016

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

712993

BMH2
Protein BMH2

1

1

High-throughput

0.479

High

837417

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

356678

H4
Histone H4

1

0

High-throughput

0.458

High

407272

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

419498

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

527046

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

653129

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.458

High

663119

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

688395

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

694206

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

706991

MSN2
Zinc finger protein MSN2

1

0

High-throughput

0.458

High

728304

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

731517

DOA1
Protein DOA1

1

0

Small-scale

0.458

High

742964

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

866427

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

902022

H3
Histone H3

1

0

High-throughput

0.458

High

961470

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

974423

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

974424

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

974427

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

974430

PBP4
Protein PBP4

1

0

High-throughput

0.458

High

974434

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

974435

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

974437

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

457063

SWI6
Regulatory protein SWI6

1

1

High-throughput

0.445

High

628891

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

695377

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

769281

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

544296

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

355607

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

515080

MCM1
Pheromone receptor transcription factor

1

0

High-throughput

0.426

High

628397

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

733296

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

744566

SWD3
COMPASS component SWD3

1

0

High-throughput

0.426

High

837456

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

970389

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.426

High

974436

RLF2
Chromatin assembly factor 1 subunit p90

1

0

High-throughput

0.426

High

687111

VPS10
Vacuolar protein sorting/targeting protein VPS10

2

0

High-throughput

0.324

High

758698

TEM1
Protein TEM1

2

0

High-throughput

0.314

High

974432

ADY3
Accumulates dyads protein 3

2

0

High-throughput

0.307

High

755661

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

946207

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

733915

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

864593

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

519987

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.265

Low

690423

HYM1
Protein HYM1

1

0

High-throughput

0.265

Low

691844

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

696553

DSS4
Protein DSS4

1

0

High-throughput

0.265

Low

697358

ISC10
Meiosis-specific protein ISC10

1

0

High-throughput

0.265

Low

748851

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.265

Low

771698

HUA1
Proline-rich protein HUA1

1

0

High-throughput

0.265

Low

811592

MRX12
MIOREX complex component 12

1

0

High-throughput

0.265

Low

973002

MUK1
Protein MUK1

1

0

High-throughput

0.265

Low

974431

YD057
Putative uncharacterized protein YDL057W

1

0

High-throughput

0.265

Low

141495

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

358229

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

383322

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405800

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

413678

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

471222

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

480279

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480847

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

482426

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

632055

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

645619

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

700594

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

706455

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

752634

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

762503

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

820137

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

967722

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

974425

PAL1
Protein PAL1

1

0

High-throughput

0.249

Low

974433

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

768380

YE18
Uncharacterized protein YER188W

1

0

High-throughput

0.238

Low

810467

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

974439

YI105
Uncharacterized protein YIL105W-A

1

0

High-throughput

0.238

Low

424678

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

588206

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

701274

VAM7
Vacuolar morphogenesis protein 7

1

0

High-throughput

0.232

Low

705570

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

773734

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

810120

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024