HitPredict

Interactor 1: TNPO2 (O14787)
Transportin-2 (Karyopherin beta-2b)
Gene: TNPO2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25754235, 23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 897 Hs			1 1210
+	Hs
		338800 TNPO1_HUMAN (2-897): 0: 625: 84.39		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383912 TNPO1_HUMAN (2-897): 0: 625: 84.39		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338188 XPO2_HUMAN (3-896): 5.07e-90: 308: 13.52		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		178088 IPO8_HUMAN (10-847): 3.45e-88: 304: 14.44		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338445 IMB1_HUMAN (11-871): 1.22e-86: 297: 17.83		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		312152 IPO7_HUMAN (11-850): 2.74e-78: 277: 13.25		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383812 IMB1_HUMAN (11-871): 1.22e-86: 297: 17.83		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338740 IPO4_HUMAN (23-761): 3.84e-35: 146: 17.15		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		127154 IPO5_HUMAN (20-627): 9.22e-15: 81.2: 10.75		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		435716 TNPO1_HUMAN (2-897): 0: 625: 84.39		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Mm
		796521 XPO2_MOUSE (3-896): 2.16e-90: 309: 13.62		ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00