HitPredict

Interactor 1: GDF8 (O14793)
Growth/differentiation factor 8 (GDF-8) (Myostatin)
Gene: MSTN

Interactor 2: AVR2B (Q13705)
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Gene: ACVR2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.80	0.702

Property	Details
Experiments	11459935, 23829672
Identification Methods	affinity chromatography technology, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 512
+	Hs
		312855 GDF11_HUMAN (33-375): 1.32e-114: 341: 63.92		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Mm
		646093 GDF11_MOUSE (39-375): 3.5e-114: 340: 65.03		AVR2B_MOUSE (1-512): 1.1e-147: 435: 93.66
+	Hs
		439886 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Hs
		59851 A4D1W7_HUMAN (1-375): 1.61e-96: 295: 22.17		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Mm
		646088 INHBA_MOUSE (1-375): 5.79e-98: 299: 22.51		AVR2A_MOUSE (3-512): 6.08e-150: 440: 67.12
+	Hs
		439881 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		AVR2A_HUMAN (3-512): 2.84e-150: 441: 67.32
+	Hs
		574203 BMP7_HUMAN (44-374): 1.37e-92: 285: 20.20		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Mm
		646092 INHBA_MOUSE (1-375): 5.79e-98: 299: 22.51		AVR2B_MOUSE (1-512): 1.1e-147: 435: 93.66
+	Hs
		574181 BMP7_HUMAN (44-374): 1.37e-92: 285: 20.20		AVR2A_HUMAN (3-512): 2.84e-150: 441: 67.32
+	Mm
		1225203 GDF11_MOUSE (39-375): 3.5e-114: 340: 65.03		ACV1C_MOUSE (59-481): 6.44e-126: 378: 33.55
+	Mm
		1145509 GDF11_MOUSE (39-375): 3.5e-114: 340: 65.03		TGFR1_MOUSE (59-486): 7.03e-122: 368: 31.30
+	Hs
		439885 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		ACVR1_HUMAN (39-492): 3.02e-134: 400: 30.39
+	Hs
		574199 BMP7_HUMAN (44-374): 1.37e-92: 285: 20.20		ACVR1_HUMAN (39-492): 3.02e-134: 400: 30.39
+	Hs
		439887 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		BMPR2_HUMAN (4-502): 3.62e-122: 384: 33.84
+	Mm
		1142443 GDF11_MOUSE (39-375): 3.5e-114: 340: 65.03		ACV1B_MOUSE (3-481): 4.67e-109: 335: 29.47
+	Hs
		122282 BMP7_HUMAN (44-374): 1.37e-92: 285: 20.20		BMR1B_HUMAN (58-486): 1.94e-126: 380: 32.39
+	Hs
		439883 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		ACVL1_HUMAN (48-484): 2.28e-114: 348: 30.93
+	Hs
		574186 BMP7_HUMAN (44-374): 1.37e-92: 285: 20.20		BMR1A_HUMAN (58-486): 1.16e-117: 358: 30.02
+	Mm
		982854 INHBA_MOUSE (1-375): 5.79e-98: 299: 22.51		ACV1B_MOUSE (3-481): 4.67e-109: 335: 29.47
+	Hs
		439882 INHBA_HUMAN (1-375): 1.61e-96: 295: 22.17		ACV1B_HUMAN (3-481): 6.79e-110: 337: 28.88