Protein: SUV91
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)

Gene: SUV91, SUV39H1
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43463

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000775 - chromosome, centromeric region
GO:0000792 - heterochromatin
GO:0000794 - condensed nuclear chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

216389

CBX5
Chromobox protein homolog 5

13

20

Small-scale

0.985

High

216410

H31
Histone H3.1

8

20

Small-scale

0.963

High

216425

CBX3
Chromobox protein homolog 3

5

20

High-throughput

0.931

High

216413

CBX1
Chromobox protein homolog 1

5

20

Small-scale

0.926

High

216441

SETB1
Histone-lysine N-methyltransferase SETDB1

4

16

Small-scale

0.899

High

216545

EHMT1
Histone-lysine N-methyltransferase EHMT1

3

15

Small-scale

0.861

High

129615

CBX4
E3 SUMO-protein ligase CBX4

2

20

Small-scale

0.836

High

216517

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

15

Small-scale

0.811

High

216498

TRI41
E3 ubiquitin-protein ligase TRIM41

2

2

High-throughput

0.783

High

216415

H33
Histone H3.3

2

20

Small-scale

0.768

High

216379

DNMT1
DNA

2

12

Small-scale

0.754

High

216444

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.740

High

216454

PHF19
PHD finger protein 19

1

8

High-throughput

0.740

High

216455

DCAF8
DDB1- and CUL4-associated factor 8

1

7

High-throughput

0.740

High

216573

DNM3A
DNA

1

9

Small-scale

0.724

High

216354

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.691

High

216438

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.691

High

216447

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.691

High

216481

H2A2B
Histone H2A type 2-B

1

4

High-throughput

0.691

High

216528

LZTS2
Leucine zipper putative tumor suppressor 2

3

3

High-throughput

0.675

High

216574

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.665

High

216421

MECOM
Histone-lysine N-methyltransferase MECOM

3

5

Small-scale

0.664

High

216507

SPSB1
SPRY domain-containing SOCS box protein 1

1

1

High-throughput

0.662

High

216462

H3C
Histone H3.3C

1

20

High-throughput

0.656

High

216485

WDFY3
WD repeat and FYVE domain-containing protein 3

1

2

High-throughput

0.656

High

216570

MTF2
Metal-response element-binding transcription factor 2

1

8

High-throughput

0.656

High

216348

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

14

Small-scale

0.647

High

216423

RBBP4
Histone-binding protein RBBP4

1

13

Small-scale

0.647

High

216446

RBBP7
Histone-binding protein RBBP7

1

13

Small-scale

0.647

High

216473

H32
Histone H3.2

1

20

Small-scale

0.647

High

216552

DNM3B
DNA

1

9

Small-scale

0.647

High

216510

HOOK2
Protein Hook homolog 2

4

1

High-throughput

0.642

High

216417

MDM2
E3 ubiquitin-protein ligase Mdm2

3

1

Small-scale

0.640

High

216419

RUNX1
Runt-related transcription factor 1

2

2

Small-scale

0.639

High

216430

HDAC1
Histone deacetylase 1

2

11

Small-scale

0.634

High

216501

HDAC2
Histone deacetylase 2

2

11

Small-scale

0.634

High

216352

MAGC1
Melanoma-associated antigen C1

2

4

High-throughput

0.628

High

216456

DDI2
Protein DDI1 homolog 2

2

1

High-throughput

0.628

High

216470

MCAF1
Activating transcription factor 7-interacting protein 1

2

5

High-throughput

0.628

High

216472

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

2

5

High-throughput

0.628

High

216504

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

High-throughput

0.628

High

216539

ENKD1
Enkurin domain-containing protein 1

2

1

High-throughput

0.628

High

216542

ZN644
Zinc finger protein 644

2

11

High-throughput

0.628

High

216562

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

5

High-throughput

0.628

High

216366

RB
Retinoblastoma-associated protein

2

3

Small-scale

0.624

High

216431

CUL4B
Cullin-4B

2

6

Small-scale

0.624

High

216445

DDB1
DNA damage-binding protein 1

2

2

Small-scale

0.624

High

216509

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

4

Small-scale

0.621

High

216486

DAW1
Dynein assembly factor with WD repeat domains 1

1

4

High-throughput

0.618

High

216353

H2B1K
Histone H2B type 1-K

1

12

High-throughput

0.618

High

216427

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.618

High

216524

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

7

Small-scale

0.618

High

216406

KR107
Keratin-associated protein 10-7

3

1

High-throughput

0.616

High

216475

ZN438
Zinc finger protein 438

2

5

High-throughput

0.606

High

216489

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

3

High-throughput

0.606

High

216493

ZN417
Zinc finger protein 417

2

1

High-throughput

0.606

High

216515

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

1

High-throughput

0.606

High

216555

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.606

High

216440

ABRX2
BRISC complex subunit Abraxas 2

2

0

High-throughput

0.602

High

216531

MCMBP
Mini-chromosome maintenance complex-binding protein

2

0

High-throughput

0.602

High

216547

M1IP1
Mid1-interacting protein 1

2

0

High-throughput

0.602

High

216554

DAXX
Death domain-associated protein 6

2

0

Small-scale

0.585

High

216467

PADI6
Inactive protein-arginine deiminase type-6

2

0

High-throughput

0.580

High

216499

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

216558

MBD1
Methyl-CpG-binding domain protein 1

1

6

Small-scale

0.578

High

216457

H37
Histone H3-7

1

20

High-throughput

0.575

High

216367

HXC4
Homeobox protein Hox-C4

1

3

High-throughput

0.573

High

216392

HXA1
Homeobox protein Hox-A1

1

2

High-throughput

0.573

High

216394

CLK3
Dual specificity protein kinase CLK3

1

2

High-throughput

0.573

High

216397

RASF2
Ras association domain-containing protein 2

1

2

High-throughput

0.573

High

216418

U2AF1
Splicing factor U2AF 35 kDa subunit

1

1

High-throughput

0.573

High

216424

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.573

High

216488

STX19
Syntaxin-19

1

1

High-throughput

0.573

High

216529

ZN649
Zinc finger protein 649

1

1

High-throughput

0.573

High

216530

ZN670
Zinc finger protein 670

1

6

High-throughput

0.573

High

216533

CDCA4
Cell division cycle-associated protein 4

1

1

High-throughput

0.573

High

216549

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.573

High

188111

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.561

High

216370

MYOD1
Myoblast determination protein 1

1

7

Small-scale

0.561

High

216572

CABIN
Calcineurin-binding protein cabin-1

1

5

Small-scale

0.561

High

216537

BC11B
B-cell lymphoma/leukemia 11B

1

0

Small-scale

0.554

High

64989

GG6L9
Golgin subfamily A member 6-like protein 9

2

3

High-throughput

0.553

High

216407

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

216459

TENS2
Tensin-2

2

0

High-throughput

0.551

High

216494

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

216359

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.549

High

216408

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.549

High

216471

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.549

High

216536

ZN436
Zinc finger protein 436

1

0

High-throughput

0.549

High

216550

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.549

High

216567

ZKSC5
Zinc finger protein with KRAB and SCAN domains 5

1

0

High-throughput

0.549

High

216362

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.536

High

216374

TCPA
T-complex protein 1 subunit alpha

1

10

High-throughput

0.536

High

216399

TCPD
T-complex protein 1 subunit delta

1

9

High-throughput

0.536

High

216439

NUMA1
Nuclear mitotic apparatus protein 1

1

5

High-throughput

0.536

High

216482

MGAP
MAX gene-associated protein

1

1

High-throughput

0.536

High

216506

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.536

High

216527

KLDC3
Kelch domain-containing protein 3

1

4

High-throughput

0.536

High

216556

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.536

High

63283

ODAD3
Outer dynein arm-docking complex subunit 3

1

2

High-throughput

0.523

High

216463

CH074
Uncharacterized protein C8orf74

1

1

High-throughput

0.523

High

216496

KLDC4
Kelch domain-containing protein 4

1

4

High-throughput

0.523

High

216492

CEP70
Centrosomal protein of 70 kDa

1

1

High-throughput

0.523

High

216442

Q15156
Protein PML

1

20

Small-scale

0.515

High

216402

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.515

High

216477

Q86V38
Atrophin 1

1

6

High-throughput

0.515

High

216349

ZN292
Zinc finger protein 292

1

0

High-throughput

0.513

High

216377

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.513

High

216380

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

216401

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

216412

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

216534

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.513

High

216544

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.513

High

208143

RRP8
Ribosomal RNA-processing protein 8

1

0

Small-scale

0.512

High

193835

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

2

High-throughput

0.508

High

208768

ZBT24
Zinc finger and BTB domain-containing protein 24

1

4

High-throughput

0.508

High

216350

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.508

High

216356

STX11
Syntaxin-11

1

1

High-throughput

0.508

High

216357

MBD4
Methyl-CpG-binding domain protein 4

1

5

High-throughput

0.508

High

216361

WIZ
Protein Wiz

1

10

High-throughput

0.508

High

216365

FYN
Tyrosine-protein kinase Fyn

1

2

High-throughput

0.508

High

216375

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

7

High-throughput

0.508

High

216384

FUS
RNA-binding protein FUS

1

5

High-throughput

0.508

High

216388

ID1
DNA-binding protein inhibitor ID-1

1

2

High-throughput

0.508

High

216395

ZN165
Zinc finger protein 165

1

3

High-throughput

0.508

High

216403

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.508

High

216420

ID2
DNA-binding protein inhibitor ID-2

1

2

High-throughput

0.508

High

216433

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

1

High-throughput

0.508

High

216435

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

4

High-throughput

0.508

High

216448

ZN829
Zinc finger protein 829

1

3

High-throughput

0.508

High

216461

LHX8
LIM/homeobox protein Lhx8

1

9

High-throughput

0.508

High

216484

SLN12
Ribonuclease SLFN12

1

2

High-throughput

0.508

High

216495

LNX1
E3 ubiquitin-protein ligase LNX

1

3

High-throughput

0.508

High

216497

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

2

High-throughput

0.508

High

216520

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.508

High

216546

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.508

High

216557

KLF15
Krueppel-like factor 15

1

18

High-throughput

0.508

High

216559

CDC23
Cell division cycle protein 23 homolog

1

1

High-throughput

0.508

High

216561

ING4
Inhibitor of growth protein 4

1

1

High-throughput

0.508

High

216571

ZN451
E3 SUMO-protein ligase ZNF451

1

3

High-throughput

0.508

High

216364

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

216369

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.501

High

216436

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

3

Small-scale

0.500

High

216386

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

216502

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

216363

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

216387

TCPZ
T-complex protein 1 subunit zeta

1

9

High-throughput

0.489

High

216390

TCPE
T-complex protein 1 subunit epsilon

1

12

High-throughput

0.489

High

216391

TCPG
T-complex protein 1 subunit gamma

1

12

High-throughput

0.489

High

216398

TCPQ
T-complex protein 1 subunit theta

1

14

High-throughput

0.489

High

216411

TCPB
T-complex protein 1 subunit beta

1

11

High-throughput

0.489

High

216526

TCPH
T-complex protein 1 subunit eta

1

12

High-throughput

0.489

High

216372

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.486

High

216393

PRI2
DNA primase large subunit

1

0

High-throughput

0.486

High

216405

ELOF1
Transcription elongation factor 1 homolog

1

0

High-throughput

0.486

High

216453

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.486

High

216465

T2H2L
General transcription factor IIH subunit 2-like protein

1

0

High-throughput

0.486

High

216466

FOXR2
Forkhead box protein R2

1

0

High-throughput

0.486

High

216476

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.486

High

216478

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.486

High

216491

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.486

High

216511

MCRS1
Microspherule protein 1

1

0

High-throughput

0.486

High

216513

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.486

High

216518

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.486

High

216519

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.486

High

216522

CRBN
Protein cereblon

1

0

High-throughput

0.486

High

216523

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.486

High

216535

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.486

High

216538

INT2
Integrator complex subunit 2

1

0

High-throughput

0.486

High

216553

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

0

High-throughput

0.486

High

216490

ZN557
Zinc finger protein 557

1

3

High-throughput

0.481

High

216551

ZN581
Zinc finger protein 581

1

3

High-throughput

0.481

High

156724

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

216360

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

216368

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

216373

TAL1
T-cell acute lymphocytic leukemia protein 1

1

5

Small-scale

0.479

High

216378

MCM3
DNA replication licensing factor MCM3

1

2

High-throughput

0.479

High

216381

RBL1
Retinoblastoma-like protein 1

1

3

Small-scale

0.479

High

216382

PML
Protein PML

1

7

Small-scale

0.479

High

216383

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

216400

MECP2
Methyl-CpG-binding protein 2

1

8

Small-scale

0.479

High

216404

HDAC4
Histone deacetylase 4

1

14

Small-scale

0.479

High

216414

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

216416

VIGLN
Vigilin

1

2

Small-scale

0.479

High

216422

RBL2
Retinoblastoma-like protein 2

1

3

Small-scale

0.479

High

216426

STK3
Serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

216429

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

Small-scale

0.479

High

216432

RUNX3
Runt-related transcription factor 3

1

2

Small-scale

0.479

High

216434

RUNX2
Runt-related transcription factor 2

1

2

Small-scale

0.479

High

216437

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

216451

ESCO2
N-acetyltransferase ESCO2

1

3

Small-scale

0.479

High

216452

ESCO1
N-acetyltransferase ESCO1

1

3

Small-scale

0.479

High

216458

GFI1B
Zinc finger protein Gfi-1b

1

7

Small-scale

0.479

High

216464

CDC73
Parafibromin

1

1

Small-scale

0.479

High

216474

SPT6H
Transcription elongation factor SPT6

1

3

High-throughput

0.479

High

216480

PHF13
PHD finger protein 13

1

1

Small-scale

0.479

High

216483

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.479

High

216500

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

216505

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

216521

PRAM
PML-RARA-regulated adapter molecule 1

1

5

Small-scale

0.479

High

216525

SMAD5
Mothers against decapentaplegic homolog 5

1

6

Small-scale

0.479

High

216560

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

216565

HDAC5
Histone deacetylase 5

1

14

Small-scale

0.479

High

216566

RUVB2
RuvB-like 2

1

2

Small-scale

0.479

High

216449

CP100
Cilia- and flagella-associated protein 100

1

1

High-throughput

0.464

High

216385

AHR
Aryl hydrocarbon receptor

1

0

Small-scale

0.458

High

216409

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

216487

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

216508

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

216512

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.458

High

216563

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.458

High

216564

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

216460

ZNF57
Zinc finger protein 57

1

1

High-throughput

0.457

High

58764

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.445

High

216503

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.316

High

216532

GTPB2
GTP-binding protein 2

1

0

High-throughput

0.299

High

216355

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

216428

PHLP
Phosducin-like protein

1

0

High-throughput

0.279

Low

216548

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

216396

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

212745

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.265

Low

216371

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.265

Low

216376

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.265

Low

216450

CD017
Uncharacterized protein C4orf17

1

0

High-throughput

0.265

Low

216468

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.265

Low

216469

RSPO2
R-spondin-2

1

0

High-throughput

0.265

Low

216479

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.265

Low

216514

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.265

Low

216516

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.265

Low

216543

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.265

Low

216568

KLH20
Kelch-like protein 20

1

0

High-throughput

0.265

Low

216569

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.265

Low

216443

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.251

Low

216351

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

Small-scale

0.249

Low

216358

MTMR5
Myotubularin-related protein 5

1

0

Small-scale

0.249

Low

216540

FA83D
Protein FAM83D

1

0

High-throughput

0.249

Low

216541

FBX44
F-box only protein 44

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025