HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: SLAF5 (Q9UIB8)
SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
Gene: CD84

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	12115647, 23322602, 12928397
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 345
+	Hs
		155852 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF6_HUMAN (3-345): 1.05e-52: 178: 26.00
+	Mm
		991971 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		CD244_MOUSE (1-344): 1.81e-49: 172: 17.40
+	Hs
		243153 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF6_HUMAN (3-345): 1.05e-52: 178: 26.00
+	Mm
		1115123 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Mm
		1061798 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Mm
		192617 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Hs
		155840 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Hs
		412176 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Mm
		192616 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF7_MOUSE (1-345): 5.96e-45: 158: 27.73
+	Hs
		243137 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Mm
		763408 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Hs
		411939 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD2_HUMAN (2-342): 4.75e-43: 153: 18.57
+	Hs
		176495 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		155856 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		155857 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF7_HUMAN (5-345): 2.26e-40: 146: 28.37
+	Hs
		412347 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		243155 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		243158 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF7_HUMAN (5-345): 2.26e-40: 146: 28.37
+	Hs
		155860 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ROBO1_HUMAN (14-332): 2.51e-33: 132: 13.86
+	Hs
		243157 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		LY9_HUMAN (13-254): 6.07e-34: 133: 29.84