Protein: DPYL2
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)

Gene: DPYL2, DPYSL2
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q16555

Gene Ontology (top 5):
GO:0004157 - dihydropyrimidinase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005929 - cilium
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1123248

DPYL3
Dihydropyrimidinase-related protein 3

10

17

High-throughput

0.978

High

1158698

DPYL5
Dihydropyrimidinase-related protein 5

7

18

High-throughput

0.971

High

1158660

DPYL2
Dihydropyrimidinase-related protein 2

6

18

High-throughput

0.942

High

1123198

DPYL1
Dihydropyrimidinase-related protein 1

5

18

Small-scale

0.925

High

155854

DPYL4
Dihydropyrimidinase-related protein 4

3

17

High-throughput

0.854

High

1120600

DPYS
Dihydropyrimidinase

2

16

High-throughput

0.811

High

1158709

GORS2
Golgi reassembly-stacking protein 2

5

1

High-throughput

0.722

High

1158715

KTU
Protein kintoun

3

5

High-throughput

0.667

High

868702

LEG7
Galectin-7

2

3

High-throughput

0.611

High

1158661

DGUOK
Deoxyguanosine kinase, mitochondrial

2

4

High-throughput

0.611

High

1158699

KLDC3
Kelch domain-containing protein 3

2

5

High-throughput

0.611

High

1158716

ARMC1
Armadillo repeat-containing protein 1

2

3

High-throughput

0.611

High

124361

HAX1
HCLS1-associated protein X-1

3

5

High-throughput

0.609

High

1158700

WDR83
WD repeat domain-containing protein 83

3

4

High-throughput

0.609

High

1158720

NUFP1
FMR1-interacting protein NUFIP1

3

4

High-throughput

0.609

High

830820

CCNF
Cyclin-F

2

3

High-throughput

0.601

High

1158677

Q8IXW6
Dihydropyrimidinase-like 3

1

18

High-throughput

0.594

High

1158714

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.590

High

843595

HD
Huntingtin

2

6

High-throughput

0.588

High

241811

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

1115684

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

8

High-throughput

0.584

High

1158723

TNIK
TRAF2 and NCK-interacting protein kinase

2

6

High-throughput

0.576

High

1158672

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

537232

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.571

High

934675

TERA
Transitional endoplasmic reticulum ATPase

2

10

High-throughput

0.571

High

889284

NUMB
Protein numb homolog

1

2

Small-scale

0.561

High

344699

AP2A1
AP-2 complex subunit alpha-1

1

0

Small-scale

0.537

High

529881

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.536

High

540021

BCR
Breakpoint cluster region protein

1

5

High-throughput

0.536

High

906887

GPM6A
Neuronal membrane glycoprotein M6-a

1

4

High-throughput

0.536

High

1140071

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

3

High-throughput

0.536

High

1158666

SPSB3
SPRY domain-containing SOCS box protein 3

1

9

High-throughput

0.536

High

1158684

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.536

High

1158701

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

1158702

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.536

High

1158722

CDC23
Cell division cycle protein 23 homolog

1

1

High-throughput

0.536

High

1158727

X5DQV1
Dihydropyrimidinase-related protein 1

1

18

High-throughput

0.528

High

249142

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.518

High

716383

BLVRB
Flavin reductase

1

0

High-throughput

0.513

High

920699

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.513

High

955217

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

993595

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

1158721

LEF1
Lymphoid enhancer-binding factor 1

1

2

High-throughput

0.494

High

1158676

TF2LY
Homeobox protein TGIF2LY

1

1

High-throughput

0.489

High

1158688

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.489

High

1158695

MMAB
Corrinoid adenosyltransferase MMAB

1

2

High-throughput

0.489

High

1137621

EXOS7
Exosome complex component RRP42

1

3

High-throughput

0.481

High

132071

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

8

High-throughput

0.479

High

218229

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

345884

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

412002

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

422180

A4
Amyloid-beta precursor protein

1

1

Small-scale

0.479

High

457471

TBB5
Tubulin beta chain

1

7

High-throughput

0.479

High

651344

CBL
E3 ubiquitin-protein ligase CBL

1

5

High-throughput

0.479

High

667881

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

732325

PRDX2
Peroxiredoxin-2

1

3

Small-scale

0.479

High

786627

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

862176

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

888098

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

891583

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.479

High

904772

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

964977

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

967762

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.479

High

970576

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

1047423

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

1098523

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

7

Small-scale

0.479

High

1100803

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

1111452

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

1

High-throughput

0.479

High

1113212

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1141628

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1146685

PCBP1
Poly(rC)-binding protein 1

1

1

Small-scale

0.479

High

1158662

BOREA
Borealin

1

2

High-throughput

0.479

High

1158664

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1158665

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1158667

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1158668

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

1158670

TBA1A
Tubulin alpha-1A chain

1

13

High-throughput

0.479

High

1158673

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

1

High-throughput

0.479

High

1158674

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1158680

NIN
Ninein

1

1

High-throughput

0.479

High

1158682

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1158683

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1158686

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

2

Small-scale

0.479

High

1158687

BICD2
Protein bicaudal D homolog 2

1

5

High-throughput

0.479

High

1158690

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1158693

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

1158694

SPDLY
Protein Spindly

1

4

High-throughput

0.479

High

1158706

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.479

High

1158707

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1158712

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1158718

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

1

High-throughput

0.479

High

1158719

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1158724

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

1158726

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

2

High-throughput

0.479

High

327690

UBL3
Ubiquitin-like protein 3

1

0

Small-scale

0.458

High

791421

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

1158679

MILK1
MICAL-like protein 1

1

0

Small-scale

0.458

High

1158689

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1158692

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1158705

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1158710

NGB
Neuroglobin

1

0

High-throughput

0.458

High

1158717

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1130277

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

Small-scale

0.445

High

1158696

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.445

High

1158703

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1158704

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

2

High-throughput

0.445

High

1158708

VIAAT
Vesicular inhibitory amino acid transporter

1

1

High-throughput

0.445

High

1158725

S12A4
Solute carrier family 12 member 4

1

1

High-throughput

0.445

High

106007

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

260016

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

372144

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

588808

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

606823

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

695577

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768303

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1096705

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.437

High

1114850

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

1121235

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.437

High

1155411

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1158669

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1158671

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1158675

MGDP1
Magnesium-dependent phosphatase 1

1

2

High-throughput

0.437

High

1158678

F186B
Protein FAM186B

1

1

High-throughput

0.437

High

1158691

HDAC2
Histone deacetylase 2

1

5

High-throughput

0.437

High

1158713

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.437

High

133514

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

1158685

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

1158711

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.251

Low

1029849

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.249

Low

1156727

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1158663

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

1158697

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.249

Low

947001

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

62531

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

1158681

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025