HitPredict

Interactor 1: RGRF2 (O14827)
Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
Gene: RASGRF2

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11238945
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RasGEF, Ras~RasGEF_N, Ras~RhoGEF
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1237 Hs			1 189
+	Hs
		349312 RGRF1_HUMAN (1-1236): 0: 957: 63.96		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349311 RPGF1_HUMAN (595-1235): 1.34e-112: 380: 20.06		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349754 RPGF2_HUMAN (819-1201): 2.11e-96: 340: 20.93		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349519 RPGF6_HUMAN (758-1233): 3.42e-89: 320: 19.05		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		919625 RPGF1_HUMAN (595-1235): 1.34e-112: 380: 20.06		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		348818 RPGF6_HUMAN (758-1233): 3.42e-89: 320: 19.05		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		171532 RGL2_HUMAN (847-1237): 1.95e-91: 314: 22.72		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		171531 RGL2_HUMAN (847-1237): 1.95e-91: 314: 22.72		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		919656 RPGF4_HUMAN (829-1236): 2.22e-106: 361: 18.84		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		350385 RPGF6_HUMAN (758-1233): 3.42e-89: 320: 19.05		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		171533 RGL2_HUMAN (847-1237): 1.95e-91: 314: 22.72		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		919687 RPGF2_HUMAN (819-1201): 2.11e-96: 340: 20.93		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		919653 RPGF6_HUMAN (758-1233): 3.42e-89: 320: 19.05		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		313171 RPGF3_HUMAN (732-1233): 3.97e-91: 316: 16.07		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Dm
		442976 Q9VMF3_DROME (722-1202): 4.43e-88: 316: 16.77		RAP1_DROME (1-163): 3.2e-63: 194: 58.54
+	Hs
		313169 RPGF3_HUMAN (732-1233): 3.97e-91: 316: 16.07		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		171541 RGL2_HUMAN (847-1237): 1.95e-91: 314: 22.72		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Sc
		350781 CDC25_YEAST (825-1234): 3.09e-88: 316: 22.27		RAS2_YEAST (3-164): 2.5e-58: 187: 64.42
+	Sc
		350755 CDC25_YEAST (825-1234): 3.09e-88: 316: 22.27		RAS1_YEAST (3-164): 4.46e-57: 183: 63.19
+	Hs
		171535 RGL2_HUMAN (847-1237): 1.95e-91: 314: 22.72		RALA_HUMAN (4-169): 5.37e-58: 182: 53.29