Interactor 1: AIM2 (O14862)
Interferon-inducible protein AIM2 (Absent in melanoma 2)
Gene: AIM2
Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 1.00 | 0.956 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19158675, 19158676, 21575908, 24630722, 22286270, 24237704 |
| Identification Methods | anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation, electron microscopy, fluorescence polarization spectroscopy, molecular sieving |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PYRIN~PYRIN |
| Common GO terms | GO:0002218 - activation of innate immune response GO:0002221 - pattern recognition receptor signaling pathway GO:0002230 - positive regulation of defense response to virus by host GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 12 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
