Protein: SGK1
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)

Gene: SGK1
Organism: Homo sapiens
Interactions: 107
UniProt ID: O00141

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005246 - calcium channel regulator activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

122891

PDPK1
3-phosphoinositide-dependent protein kinase 1

4

16

Small-scale

0.882

High

122949

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

3

11

High-throughput

0.855

High

122889

CETN3
Centrin-3

2

1

High-throughput

0.783

High

122899

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.754

High

122976

WNK1
Serine/threonine-protein kinase WNK1

2

17

Small-scale

0.754

High

122971

NED4L
E3 ubiquitin-protein ligase NEDD4-like

7

20

Small-scale

0.742

High

122962

LPP60
60 kDa lysophospholipase

1

9

Small-scale

0.740

High

122969

WNK4
Serine/threonine-protein kinase WNK4

1

17

Small-scale

0.724

High

122930

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

6

Small-scale

0.710

High

122946

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.709

High

122887

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.691

High

122896

RASH
GTPase HRas

1

8

High-throughput

0.691

High

122931

NEDD4
E3 ubiquitin-protein ligase NEDD4

4

20

Small-scale

0.686

High

122907

TAU
Microtubule-associated protein tau

3

15

Small-scale

0.678

High

122897

PIGR
Polymeric immunoglobulin receptor

1

1

High-throughput

0.665

High

122955

CDC37
Hsp90 co-chaperone Cdc37

1

14

High-throughput

0.665

High

122885

SGK1
Serine/threonine-protein kinase Sgk1

1

18

Small-scale

0.647

High

122905

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.647

High

122954

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

Small-scale

0.639

High

122926

MTOR
Serine/threonine-protein kinase mTOR

2

19

Small-scale

0.639

High

122959

RICTR
Rapamycin-insensitive companion of mTOR

2

7

Small-scale

0.619

High

122902

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

122904

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

122906

RAP2A
Ras-related protein Rap-2a

1

5

High-throughput

0.618

High

122908

PABP1
Polyadenylate-binding protein 1

1

7

High-throughput

0.618

High

122911

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

5

High-throughput

0.618

High

122937

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

High-throughput

0.618

High

122972

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

15

Small-scale

0.618

High

122985

WNK2
Serine/threonine-protein kinase WNK2

1

17

Small-scale

0.618

High

122970

ARL5B
ADP-ribosylation factor-like protein 5B

2

4

High-throughput

0.611

High

122981

NDRG4
Protein NDRG4

2

2

High-throughput

0.606

High

122973

T22D3
TSC22 domain family protein 3

2

3

Small-scale

0.584

High

122982

CHIP
E3 ubiquitin-protein ligase CHIP

2

7

Small-scale

0.584

High

122974

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

14

Small-scale

0.575

High

122938

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.573

High

122984

CHSP1
Calcium-regulated heat-stable protein 1

1

3

Small-scale

0.568

High

122928

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

9

Small-scale

0.561

High

122988

NEMO
NF-kappa-B essential modulator

1

19

High-throughput

0.561

High

122967

MAL2
Protein MAL2

2

1

High-throughput

0.553

High

122929

MAGA1
Melanoma-associated antigen 1

1

5

Small-scale

0.541

High

122950

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.537

High

122980

PRAF1
Prenylated Rab acceptor protein 1

1

0

High-throughput

0.518

High

122898

TRFL
Lactotransferrin

1

1

High-throughput

0.515

High

122915

TNR5
Tumor necrosis factor receptor superfamily member 5

1

9

High-throughput

0.515

High

122933

EFTU
Elongation factor Tu, mitochondrial

1

9

High-throughput

0.515

High

122934

TSC2
Tuberin

1

1

Small-scale

0.515

High

122939

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.515

High

122945

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

6

High-throughput

0.515

High

122983

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.515

High

122925

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

9

Small-scale

0.501

High

122943

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.501

High

122953

PDK1
[Pyruvate dehydrogenase

1

6

Small-scale

0.501

High

122966

NDRG1
Protein NDRG1

1

2

Small-scale

0.501

High

122975

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

5

Small-scale

0.501

High

122913

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.500

High

122920

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.493

High

122987

CSDC2
Cold shock domain-containing protein C2

1

3

Small-scale

0.484

High

122890

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.481

High

122927

AF9
Protein AF-9

1

0

Small-scale

0.480

High

104268

PAL4D
Peptidyl-prolyl cis-trans isomerase A-like 4D

1

3

High-throughput

0.479

High

122886

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.479

High

122892

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

122893

CBR3
Carbonyl reductase [NADPH] 3

1

3

High-throughput

0.479

High

122900

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

6

High-throughput

0.479

High

122901

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

8

High-throughput

0.479

High

122903

MCR
Mineralocorticoid receptor

1

18

Small-scale

0.479

High

122910

MYH1
Myosin-1

1

5

High-throughput

0.479

High

122912

EZRI
Ezrin

1

10

High-throughput

0.479

High

122914

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

122916

DDX6
Probable ATP-dependent RNA helicase DDX6

1

11

High-throughput

0.479

High

122917

SYVC
Valine--tRNA ligase

1

6

High-throughput

0.479

High

122918

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

122919

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

1

High-throughput

0.479

High

122921

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

122922

CTNB1
Catenin beta-1

1

6

Small-scale

0.479

High

122923

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

122924

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

122932

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

122935

GDIB
Rab GDP dissociation inhibitor beta

1

2

High-throughput

0.479

High

122941

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.479

High

122942

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

122944

CDC20
Cell division cycle protein 20 homolog

1

10

High-throughput

0.479

High

122947

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.479

High

122952

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

3

High-throughput

0.479

High

122956

FSCN1
Fascin

1

4

High-throughput

0.479

High

122957

FA98B
Protein FAM98B

1

1

High-throughput

0.479

High

122958

Q6NVI1
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

122960

MYH14
Myosin-14

1

6

High-throughput

0.479

High

122961

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

9

Small-scale

0.479

High

122963

RPTOR
Regulatory-associated protein of mTOR

1

15

Small-scale

0.479

High

122964

COMD1
COMM domain-containing protein 1

1

1

Small-scale

0.479

High

122965

IPO4
Importin-4

1

3

High-throughput

0.479

High

122968

AKTS1
Proline-rich AKT1 substrate 1

1

4

Small-scale

0.479

High

122977

MOB1A
MOB kinase activator 1A

1

1

High-throughput

0.479

High

122978

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

122986

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

122895

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.460

High

122888

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.458

High

122894

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

122909

PIP
Prolactin-inducible protein

1

0

High-throughput

0.458

High

122936

SCNNB
Epithelial sodium channel subunit beta

1

0

Small-scale

0.458

High

122940

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.458

High

122948

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.458

High

122951

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.437

High

122979

T184C
Transmembrane protein 184C

1

0

High-throughput

0.282

High

49360

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025