HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	25636800, 18207245, 21903422, 16177806
Identification Methods	enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 540
+	Hs
		167574 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		158388 IKKB_HUMAN (1-756): 0: 662: 100.00		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		1050231 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		799601 IKKA_MOUSE (1-742): 3.39e-172: 514: 50.20		CBP_MOUSE (82-395): 1.15e-11: 69.8: 14.24
+	Hs
		1190121 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		568717 KAPCA_HUMAN (4-283): 2.67e-90: 288: 27.66		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00