Protein: ANK3
Ankyrin-3 (ANK-3) (Ankyrin-G)

Gene: ANK3
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q12955

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0005200 - structural constituent of cytoskeleton
GO:0005764 - lysosome
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091467

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

11

High-throughput

0.861

High

139377

NCHL1
Neural cell adhesion molecule L1-like protein

2

8

High-throughput

0.811

High

1082533

NEXN
Nexilin

2

9

High-throughput

0.811

High

1091477

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

3

High-throughput

0.811

High

1091420

MICA3
[F-actin]-monooxygenase MICAL3

2

18

Small-scale

0.737

High

1091408

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.698

High

239311

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

20

High-throughput

0.691

High

413730

P53
Cellular tumor antigen p53

1

1

High-throughput

0.691

High

913478

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.691

High

1091413

TTBK1
Tau-tubulin kinase 1

1

10

High-throughput

0.691

High

1091443

AJUBA
LIM domain-containing protein ajuba

1

3

High-throughput

0.691

High

861588

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

8

High-throughput

0.647

High

1006367

SRPK2
SRSF protein kinase 2

1

6

High-throughput

0.647

High

1091435

DOK4
Docking protein 4

3

0

High-throughput

0.638

High

1091450

PHAF1
Phagosome assembly factor 1

3

0

High-throughput

0.638

High

1091392

PWP1
Periodic tryptophan protein 1 homolog

2

4

High-throughput

0.628

High

1091421

RHG22
Rho GTPase-activating protein 22

2

12

High-throughput

0.628

High

1091440

RPGF5
Rap guanine nucleotide exchange factor 5

2

3

High-throughput

0.628

High

1091396

FLNC
Filamin-C

2

11

Small-scale

0.624

High

1091389

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

8

High-throughput

0.618

High

1091430

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

13

High-throughput

0.618

High

125891

ARVC
Splicing regulator ARVCF

1

8

High-throughput

0.618

High

126571

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.618

High

174752

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

20

High-throughput

0.618

High

177209

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.618

High

243932

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

8

High-throughput

0.618

High

254126

CTND1
Catenin delta-1

1

8

High-throughput

0.618

High

341040

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.618

High

363206

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.618

High

375464

RASK
GTPase KRas

1

8

High-throughput

0.618

High

400742

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.618

High

440051

LCK
Tyrosine-protein kinase Lck

1

4

High-throughput

0.618

High

463487

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.618

High

541458

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.618

High

593351

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.618

High

710207

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.618

High

710822

EPHB2
Ephrin type-B receptor 2

1

7

High-throughput

0.618

High

764706

CTNB1
Catenin beta-1

1

4

High-throughput

0.618

High

830645

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

845620

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

862639

UTRN
Utrophin

1

17

High-throughput

0.618

High

919920

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.618

High

955105

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.618

High

961998

RHOA
Transforming protein RhoA

1

7

High-throughput

0.618

High

962725

RND3
Rho-related GTP-binding protein RhoE

1

10

High-throughput

0.618

High

977967

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.618

High

988324

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.618

High

1005357

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

3

High-throughput

0.618

High

1015396

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.618

High

1028748

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.618

High

1091393

CUL3
Cullin-3

1

8

High-throughput

0.618

High

1091395

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

19

High-throughput

0.618

High

1091402

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1091406

NTRK3
NT-3 growth factor receptor

1

13

High-throughput

0.618

High

1091419

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.618

High

1091423

LIPB1
Liprin-beta-1

1

4

High-throughput

0.618

High

1091429

ARL14
ADP-ribosylation factor-like protein 14

1

2

High-throughput

0.618

High

1091457

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

20

Small-scale

0.618

High

1091463

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

4

High-throughput

0.618

High

1091464

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.618

High

1091483

NS1BP
Influenza virus NS1A-binding protein

1

2

High-throughput

0.618

High

629821

BTF3
Transcription factor BTF3

2

1

High-throughput

0.611

High

1091448

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.602

High

1091404

SMAD2
Mothers against decapentaplegic homolog 2

2

3

High-throughput

0.600

High

943925

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

17

High-throughput

0.590

High

1091473

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.590

High

975008

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.586

High

1060026

SCN1B
Sodium channel regulatory subunit beta-1

1

0

Small-scale

0.586

High

1091410

KMT5B
Histone-lysine N-methyltransferase KMT5B

1

0

High-throughput

0.586

High

582768

EZRI
Ezrin

2

9

High-throughput

0.584

High

656107

PPIB
Peptidyl-prolyl cis-trans isomerase B

2

3

High-throughput

0.584

High

764320

CTNA1
Catenin alpha-1

2

2

Small-scale

0.584

High

888018

MCM2
DNA replication licensing factor MCM2

2

3

High-throughput

0.584

High

998263

H31
Histone H3.1

2

3

High-throughput

0.584

High

1091417

LIRA6
Leukocyte immunoglobulin-like receptor subfamily A member 6

2

4

High-throughput

0.584

High

254997

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.575

High

1091401

PLEC
Plectin

1

14

Small-scale

0.573

High

1091479

PLAK2
PALM2-AKAP2 fusion protein

3

3

High-throughput

0.569

High

1091441

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

Small-scale

0.561

High

1091461

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

15

High-throughput

0.555

High

1091394

CUL4A
Cullin-4A

1

8

High-throughput

0.553

High

1091418

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

126099

AP3B1
AP-3 complex subunit beta-1

1

2

Small-scale

0.552

High

529718

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.536

High

761215

RYK
Tyrosine-protein kinase RYK

1

12

High-throughput

0.536

High

961167

FGF12
Fibroblast growth factor 12

1

10

High-throughput

0.536

High

1091399

TTLL4
Tubulin monoglutamylase TTLL4

1

1

High-throughput

0.536

High

257244

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.513

High

1091437

BSND
Barttin

1

0

High-throughput

0.513

High

1014492

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.508

High

327980

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

15

Small-scale

0.501

High

862088

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.501

High

1091397

SCN5A
Sodium channel protein type 5 subunit alpha

1

5

Small-scale

0.501

High

1091452

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

15

Small-scale

0.501

High

1091460

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

15

Small-scale

0.501

High

881893

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.493

High

1091438

H1X
Histone H1.10

1

0

High-throughput

0.493

High

551017

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.489

High

1091445

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.489

High

136883

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

8

High-throughput

0.479

High

189539

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

226014

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

241539

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

278067

FLNB
Filamin-B

1

11

High-throughput

0.479

High

299171

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

324123

CE152
Centrosomal protein of 152 kDa

1

7

High-throughput

0.479

High

445850

ENOA
Alpha-enolase

1

3

High-throughput

0.479

High

446958

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

463950

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

13

High-throughput

0.479

High

468315

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

540008

BCR
Breakpoint cluster region protein

1

12

High-throughput

0.479

High

548861

ADHX
Alcohol dehydrogenase class-3

1

1

High-throughput

0.479

High

556049

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

573082

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

614685

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

1

High-throughput

0.479

High

627324

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

1

High-throughput

0.479

High

637483

FLNA
Filamin-A

1

10

High-throughput

0.479

High

642834

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

715564

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

849335

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.479

High

870466

NPBW2
Neuropeptides B/W receptor type 2

1

1

High-throughput

0.479

High

873891

KCNC1
Voltage-gated potassium channel KCNC1

1

5

Small-scale

0.479

High

986382

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1041032

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1047964

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.479

High

1070493

FCHO2
F-BAR domain only protein 2

1

3

High-throughput

0.479

High

1087090

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1091387

ABR
Active breakpoint cluster region-related protein

1

11

High-throughput

0.479

High

1091388

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

9

Small-scale

0.479

High

1091391

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

5

High-throughput

0.479

High

1091398

MCM6
DNA replication licensing factor MCM6

1

3

High-throughput

0.479

High

1091400

EEA1
Early endosome antigen 1

1

8

High-throughput

0.479

High

1091407

OCLN
Occludin

1

2

High-throughput

0.479

High

1091412

RHG21
Rho GTPase-activating protein 21

1

9

High-throughput

0.479

High

1091415

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

1091416

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1091422

PHLB2
Pleckstrin homology-like domain family B member 2

1

12

High-throughput

0.479

High

1091426

STX12
Syntaxin-12

1

4

High-throughput

0.479

High

1091428

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

4

High-throughput

0.479

High

1091432

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1091433

DLG5
Disks large homolog 5

1

4

High-throughput

0.479

High

1091434

OTU7A
OTU domain-containing protein 7A

1

8

High-throughput

0.479

High

1091439

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1091444

LRCH3
DISP complex protein LRCH3

1

4

High-throughput

0.479

High

1091446

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.479

High

1091449

LZTS2
Leucine zipper putative tumor suppressor 2

1

15

High-throughput

0.479

High

1091455

WWTR1
WW domain-containing transcription regulator protein 1

1

9

High-throughput

0.479

High

1091458

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.479

High

1091459

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1091465

E41LA
Band 4.1-like protein 4A

1

10

High-throughput

0.479

High

1091468

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

13

High-throughput

0.479

High

1091470

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1091475

ALK
ALK tyrosine kinase receptor

1

15

High-throughput

0.479

High

1091476

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.479

High

1091480

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

1091481

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

9

High-throughput

0.479

High

1091482

DTNA
Dystrobrevin alpha

1

5

High-throughput

0.479

High

424398

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.470

High

131412

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.458

High

327243

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

353298

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

571423

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.458

High

603955

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

973036

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

982416

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1091414

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.458

High

1091436

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

1

0

High-throughput

0.458

High

1091472

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.458

High

1091390

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.457

High

1091453

NDEL1
Nuclear distribution protein nudE-like 1

1

8

High-throughput

0.457

High

1091466

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

268955

LIRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3

1

4

High-throughput

0.445

High

848774

MAGAA
Melanoma-associated antigen 10

1

3

High-throughput

0.445

High

1091454

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

15

Small-scale

0.445

High

1091456

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

15

Small-scale

0.445

High

1091469

SL9A2
Sodium/hydrogen exchanger 2

1

2

High-throughput

0.445

High

1091478

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

105841

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

755697

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.437

High

1091411

SKT
Sickle tail protein homolog

1

4

High-throughput

0.437

High

1091442

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1091447

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.437

High

1091451

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.437

High

1091462

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

2

High-throughput

0.437

High

1091471

XPO7
Exportin-7

1

8

High-throughput

0.437

High

91870

C9JWL8
Leukocyte immunoglobulin like receptor B3

1

4

High-throughput

0.407

High

1091424

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

1091431

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

1091403

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.316

High

1091409

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

139860

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

181701

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low

651789

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.249

Low

1091405

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1091425

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1091427

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.249

Low

1091474

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025