HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: PJA2 (O43164)
E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)
Gene: PJA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 708
+	Hs
		196372 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		PJA2_HUMAN (1-708): 0: 580: 100.00
+	Hs
		196282 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		PJA2_HUMAN (1-708): 0: 580: 100.00
+	Hs
		196294 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		PJA2_HUMAN (1-708): 0: 580: 100.00
+	Hs
		1346940 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF12_HUMAN (124-679): 2.25e-50: 188: 15.36
+	Hs
		159102 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN150_HUMAN (536-701): 4.04e-32: 131: 21.02
+	Hs
		849459 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF12_HUMAN (124-679): 2.25e-50: 188: 15.36
+	Hs
		849491 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF6_HUMAN (67-679): 9.62e-42: 163: 13.13
+	Hs
		1313520 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN126_HUMAN (448-693): 3.37e-38: 146: 19.76
+	Hs
		849428 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN126_HUMAN (448-693): 3.37e-38: 146: 19.76
+	At
		715117 UBC8_ARATH (2-149): 2e-75: 223: 36.24		ATL78_ARATH (513-708): 2.86e-35: 134: 16.58
+	Hs
		1356934 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN150_HUMAN (536-701): 4.04e-32: 131: 21.02
+	Zm
		74334 B4FC97_MAIZE (2-149): 4.98e-76: 224: 36.24		B6U926_MAIZE (458-698): 1.68e-32: 131: 18.25
+	Zm
		79637 B6SZE0_MAIZE (2-149): 7.31e-76: 224: 35.57		B6U926_MAIZE (458-698): 1.68e-32: 131: 18.25
+	Hs
		849485 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN150_HUMAN (536-701): 4.04e-32: 131: 21.02
+	Hs
		919789 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RN149_HUMAN (536-705): 2.43e-32: 131: 21.97
+	Hs
		1377467 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN115_HUMAN (597-703): 2.39e-31: 126: 33.65
+	Hs
		849497 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN115_HUMAN (597-703): 2.39e-31: 126: 33.65
+	Hs
		1349753 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN181_HUMAN (605-686): 1.02e-30: 119: 35.37
+	Hs
		849467 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN181_HUMAN (605-686): 1.02e-30: 119: 35.37
+	At
		715128 UBC8_ARATH (2-149): 2e-75: 223: 36.24		CIP8_ARATH (585-686): 1.5e-24: 107: 25.49