HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: RN216 (Q9NWF9)
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
Gene: RNF216

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	15107846, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 866
+	Hs
		1347205 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN216_HUMAN (1-866): 0: 1150: 100.00
+	Hs
		849460 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN216_HUMAN (1-866): 0: 1150: 100.00
+	Hs
		159108 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94
+	Hs
		159008 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		849498 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94
+	Hs
		312679 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		312520 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		312553 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		159069 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		R144B_HUMAN (509-738): 8e-63: 215: 20.17
+	Hs
		159096 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN19A_HUMAN (507-744): 5.63e-57: 212: 23.83
+	Hs
		159038 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		R144A_HUMAN (512-738): 1.87e-58: 203: 24.47
+	Hs
		159068 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN19B_HUMAN (502-744): 4.49e-54: 202: 23.19
+	Hs
		1290106 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		849403 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		919819 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		1354303 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		849474 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		842095 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		R144A_HUMAN (512-738): 1.87e-58: 203: 24.47
+	Hs
		842104 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		R144A_HUMAN (512-738): 1.87e-58: 203: 24.47
+	Hs
		919757 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RN19B_HUMAN (502-744): 4.49e-54: 202: 23.19