HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28867611, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 1342
+	Hs
		159830 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		276982 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		339057 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338627 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		159848 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		276988 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		434297 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		277010 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		277037 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		435783 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		665303 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		665621 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		872668 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		159898 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		159843 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		277011 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		665436 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13