Protein: DLG4
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Gene: DLG4
Organism: Homo sapiens
Interactions: 146
UniProt ID: P78352

Gene Ontology (top 5):
GO:0002091 - negative regulation of receptor internalization
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006068

ERBB4
Receptor tyrosine-protein kinase erbB-4

4

20

Small-scale

0.903

High

208651

SI1L1
Signal-induced proliferation-associated 1-like protein 1

3

4

Small-scale

0.878

High

713159

NOS1
Nitric oxide synthase 1

3

4

Small-scale

0.877

High

1006093

SYGP1
Ras/Rap GTPase-activating protein SynGAP

3

11

Small-scale

0.845

High

1006069

RBP1
RalA-binding protein 1

2

9

High-throughput

0.800

High

1006042

DLG4
Disks large homolog 4

2

17

Small-scale

0.793

High

1006071

DLG2
Disks large homolog 2

2

17

Small-scale

0.793

High

1006087

DLG3
Disks large homolog 3

2

17

Small-scale

0.783

High

241370

PRKN
E3 ubiquitin-protein ligase parkin

2

10

Small-scale

0.776

High

1006059

NMDE2
Glutamate receptor ionotropic, NMDA 2B

22

20

Small-scale

0.767

High

1006056

NMDE1
Glutamate receptor ionotropic, NMDA 2A

18

20

Small-scale

0.765

High

648766

KCNA4
Potassium voltage-gated channel subfamily A member 4

9

20

Small-scale

0.757

High

440486

FYN
Tyrosine-protein kinase Fyn

2

17

Small-scale

0.754

High

1006123

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

15

Small-scale

0.754

High

154393

DLGP1
Disks large-associated protein 1

9

20

Small-scale

0.754

High

1006062

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.724

High

168670

CSKP
Peripheral plasma membrane protein CASK

1

15

Small-scale

0.713

High

410764

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.713

High

1006057

GRIK2
Glutamate receptor ionotropic, kainate 2

4

20

Small-scale

0.703

High

249118

DSCAM
Cell adhesion molecule DSCAM

1

11

High-throughput

0.698

High

1006046

EM55
55 kDa erythrocyte membrane protein

1

17

High-throughput

0.698

High

1006058

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

10

High-throughput

0.698

High

1006113

CRIPT
Cysteine-rich PDZ-binding protein

4

3

Small-scale

0.694

High

1006048

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

17

High-throughput

0.691

High

1006110

LIN7C
Protein lin-7 homolog C

1

19

High-throughput

0.691

High

1006107

KI13B
Kinesin-like protein KIF13B

1

19

Small-scale

0.681

High

1006051

NMDZ1
Glutamate receptor ionotropic, NMDA 1

4

20

Small-scale

0.680

High

648813

KCNA5
Potassium voltage-gated channel subfamily A member 5

3

20

Small-scale

0.669

High

1006108

PICK1
PRKCA-binding protein

1

0

High-throughput

0.663

High

870028

KCNJ4
Inward rectifier potassium channel 4

3

20

Small-scale

0.661

High

1006084

NLGN1
Neuroligin-1

3

19

Small-scale

0.658

High

245914

KIF1B
Kinesin-like protein KIF1B

1

19

Small-scale

0.653

High

167688

LIN7A
Protein lin-7 homolog A

1

20

Small-scale

0.647

High

1006066

FRPD4
FERM and PDZ domain-containing protein 4

1

12

High-throughput

0.647

High

1006081

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

14

High-throughput

0.647

High

1006102

TANC1
Protein TANC1

1

13

High-throughput

0.647

High

1006045

LRP2
Low-density lipoprotein receptor-related protein 2

2

8

Small-scale

0.633

High

472222

ADRB1
Beta-1 adrenergic receptor

2

13

Small-scale

0.631

High

1006055

KCNA1
Potassium voltage-gated channel subfamily A member 1

2

20

Small-scale

0.626

High

1006072

GRIK5
Glutamate receptor ionotropic, kainate 5

2

20

Small-scale

0.624

High

1006088

EXOC4
Exocyst complex component 4

2

3

Small-scale

0.624

High

659014

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

7

Small-scale

0.621

High

773726

ACTN2
Alpha-actinin-2

2

13

Small-scale

0.619

High

603232

KPCA
Protein kinase C alpha type

1

9

Small-scale

0.618

High

931494

RD23A
UV excision repair protein RAD23 homolog A

1

3

Small-scale

0.618

High

987532

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1006049

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

12

Small-scale

0.618

High

1006073

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

4

Small-scale

0.618

High

1006074

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1006082

PHLB2
Pleckstrin homology-like domain family B member 2

1

6

Small-scale

0.618

High

1006092

LRRC7
Leucine-rich repeat-containing protein 7

1

12

Small-scale

0.618

High

1006105

LIN7B
Protein lin-7 homolog B

1

19

Small-scale

0.618

High

1006118

DP13A
DCC-interacting protein 13-alpha

1

7

Small-scale

0.618

High

1006121

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1006125

BAIP2
BAR/IMD domain-containing adapter protein 2

1

6

Small-scale

0.618

High

1006128

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

14

Small-scale

0.618

High

732537

ARRB2
Beta-arrestin-2

1

0

Small-scale

0.614

High

350655

DLGP3
Disks large-associated protein 3

2

20

Small-scale

0.613

High

1006126

DLGP4
Disks large-associated protein 4

2

20

Small-scale

0.613

High

595035

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

20

Small-scale

0.606

High

1006053

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

9

Small-scale

0.606

High

189315

NMDE4
Glutamate receptor ionotropic, NMDA 2D

2

20

Small-scale

0.595

High

752038

GCYA2
Guanylate cyclase soluble subunit alpha-2

2

9

Small-scale

0.595

High

762199

CRFR1
Corticotropin-releasing factor receptor 1

2

10

Small-scale

0.595

High

1006065

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

20

Small-scale

0.589

High

1006061

LRP8
Low-density lipoprotein receptor-related protein 8

2

8

Small-scale

0.586

High

642796

KCNA3
Potassium voltage-gated channel subfamily A member 3

2

20

Small-scale

0.584

High

1006064

KCJ12
ATP-sensitive inward rectifier potassium channel 12

2

20

Small-scale

0.584

High

1006129

CCG2
Voltage-dependent calcium channel gamma-2 subunit

2

9

Small-scale

0.584

High

1006101

SEM4C
Semaphorin-4C

1

7

Small-scale

0.573

High

1006047

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.569

High

155238

AGRB1
Adhesion G protein-coupled receptor B1

2

10

Small-scale

0.563

High

640350

DRD1
D(1A) dopamine receptor

1

15

Small-scale

0.561

High

811286

GRIK1
Glutamate receptor ionotropic, kainate 1

1

20

Small-scale

0.561

High

991490

DYL1
Dynein light chain 1, cytoplasmic

1

7

Small-scale

0.561

High

1006089

DYL2
Dynein light chain 2, cytoplasmic

1

7

Small-scale

0.561

High

1006116

PCD10
Protocadherin-10

1

3

Small-scale

0.561

High

1006130

S4A7
Sodium bicarbonate cotransporter 3

1

3

Small-scale

0.561

High

169507

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

Small-scale

0.552

High

270445

FZD7
Frizzled-7

1

13

Small-scale

0.552

High

993069

KCNJ2
Inward rectifier potassium channel 2

1

20

Small-scale

0.552

High

1006043

MAP1A
Microtubule-associated protein 1A

1

9

Small-scale

0.552

High

239452

AGRB2
Adhesion G protein-coupled receptor B2

1

9

High-throughput

0.541

High

391606

FRIH
Ferritin heavy chain

1

1

High-throughput

0.541

High

462345

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.541

High

533637

CLUS
Clusterin

1

1

High-throughput

0.541

High

687966

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

1006044

GPSM2
G-protein-signaling modulator 2

1

7

High-throughput

0.541

High

1006054

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.541

High

1006075

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

1

1

High-throughput

0.541

High

1006078

TJAP1
Tight junction-associated protein 1

1

6

High-throughput

0.541

High

1006097

LZTS2
Leucine zipper putative tumor suppressor 2

1

8

High-throughput

0.541

High

1006099

BEGIN
Brain-enriched guanylate kinase-associated protein

1

6

High-throughput

0.541

High

1006100

TBB2B
Tubulin beta-2B chain

1

9

High-throughput

0.541

High

1006104

RASF4
Ras association domain-containing protein 4

1

1

High-throughput

0.541

High

105741

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

1006115

DLGP2
Disks large-associated protein 2

1

20

Small-scale

0.527

High

643454

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.518

High

828351

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

1006090

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.518

High

532511

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.515

High

770682

SPR2A
Small proline-rich protein 2A

1

0

Small-scale

0.513

High

1006098

LRRC1
Leucine-rich repeat-containing protein 1

1

12

Small-scale

0.508

High

702759

5HT2C
5-hydroxytryptamine receptor 2C

1

18

Small-scale

0.501

High

1006050

UBE3A
Ubiquitin-protein ligase E3A

1

11

Small-scale

0.501

High

1006094

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.501

High

1006095

PKP4
Plakophilin-4

1

12

High-throughput

0.501

High

1006106

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.501

High

1006109

CLTR2
Cysteinyl leukotriene receptor 2

1

20

High-throughput

0.501

High

1006124

CTND2
Catenin delta-2

1

10

High-throughput

0.501

High

1006127

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.501

High

1006079

WDR74
WD repeat-containing protein 74

1

3

High-throughput

0.494

High

1006085

MPND
MPN domain-containing protein

1

1

High-throughput

0.494

High

1006091

THOC3
THO complex subunit 3

1

1

High-throughput

0.494

High

1006063

FZD2
Frizzled-2

1

13

Small-scale

0.481

High

1006086

NLGN2
Neuroligin-2

1

19

Small-scale

0.481

High

1006111

NLGN3
Neuroligin-3

1

19

Small-scale

0.481

High

1006112

KCND2
A-type voltage-gated potassium channel KCND2

1

20

Small-scale

0.481

High

1006120

FZD4
Frizzled-4

1

13

Small-scale

0.481

High

1006122

FZD1
Frizzled-1

1

13

Small-scale

0.481

High

351772

LGI1
Leucine-rich glioma-inactivated protein 1

1

12

Small-scale

0.479

High

421902

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.479

High

701450

5HT2A
5-hydroxytryptamine receptor 2A

1

15

Small-scale

0.479

High

838486

GRIA2
Glutamate receptor 2

1

20

Small-scale

0.479

High

838524

GRIA3
Glutamate receptor 3

1

20

Small-scale

0.479

High

845009

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

932565

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

9

Small-scale

0.479

High

1006060

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1006077

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.479

High

1006080

ARC
Activity-regulated cytoskeleton-associated protein

1

2

Small-scale

0.479

High

1006083

NLGNX
Neuroligin-4, X-linked

1

19

Small-scale

0.479

High

1006114

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

11

Small-scale

0.479

High

1006117

ASIC3
Acid-sensing ion channel 3

1

1

Small-scale

0.479

High

1006119

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

1006131

DUS10
Dual specificity protein phosphatase 10

1

6

High-throughput

0.479

High

584676

MCP
Membrane cofactor protein

1

0

Small-scale

0.460

High

1006096

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

Small-scale

0.458

High

254959

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

404766

PRIO
Major prion protein

1

3

High-throughput

0.445

High

1006052

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

Small-scale

0.408

High

1006070

KS6A1
Ribosomal protein S6 kinase alpha-1

1

11

Small-scale

0.408

High

360267

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.282

High

1006067

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.282

High

1006076

LARGN
Protein Largen

1

0

High-throughput

0.282

High

1006103

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.269

Low


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Last updated: 11Aug2025