HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 607
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29
+	Hs
		159889 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR3_HUMAN (137-601): 1.51e-144: 440: 27.04
+	Hs
		160014 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92
+	Hs
		159885 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR2_HUMAN (139-601): 5.39e-134: 413: 26.40
+	Hs
		160015 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24
+	Hs
		159837 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65
+	Hs
		159888 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR4_HUMAN (137-604): 9.44e-129: 398: 26.10
+	Rn
		1144355 HGS_RAT (1-777): 3.19e-100: 328: 93.44		NTRK2_RAT (15-607): 6e-130: 402: 22.33
+	Mm
		546322 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		NTRK2_MOUSE (15-607): 2.45e-130: 403: 22.33
+	Hs
		159843 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		INSR_HUMAN (237-598): 1.43e-108: 357: 29.40
+	Hs
		276996 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29
+	Hs
		277004 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR3_HUMAN (137-601): 1.51e-144: 440: 27.04
+	Hs
		277014 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RYK_HUMAN (1-607): 1.73e-146: 438: 100.00
+	Hs
		277073 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92
+	Hs
		277002 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR2_HUMAN (139-601): 5.39e-134: 413: 26.40
+	Hs
		241132 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65
+	Hs
		277074 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24
+	Hs
		276985 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65
+	Hs
		277003 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR4_HUMAN (137-604): 9.44e-129: 398: 26.10
+	Hs
		159851 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		MET_HUMAN (265-593): 1.87e-59: 217: 35.95